Solomon S
Department of Medicine and Biochemistry, McGill University, Montreal, Quebec, Canada.
Ann N Y Acad Sci. 1999 Oct 20;885:22-40. doi: 10.1111/j.1749-6632.1999.tb08663.x.
It has long been known that a large number of POMC-related peptides are found in skin. In this introduction I describe the formation of POMC-derived peptides in various tissues to indicate that processing is largely tissue-dependent. I focus on the peptides from the N-terminal fragment, such as gamma-MSH, ACTH and alpha-MSH, and beta-lipopropin as well as beta-endorphin. I touch on the factors that control the synthesis of the various peptides, which are now numerous and varied, and again are tissue specific. The biologic activity of the peptides generated from POMC are described in relation to their possible action in skin. In addition, I describe a new class of peptides induced in skin following injury and which are of great interest.
长期以来，人们一直知道皮肤中存在大量与促肾上腺皮质激素原（POMC）相关的肽。在本引言中，我描述了POMC衍生肽在各种组织中的形成，以表明加工过程在很大程度上依赖于组织。我重点关注来自N端片段的肽，如γ-促黑素（γ-MSH）、促肾上腺皮质激素（ACTH）和α-促黑素（α-MSH），以及β-脂酸促肾上腺皮质激素原（β-lipopropin）和β-内啡肽。我还提到了控制各种肽合成的因素，这些因素现在众多且多样，并且同样具有组织特异性。文中描述了POMC产生的肽的生物活性与其在皮肤中可能的作用的关系。此外，我还描述了一类在皮肤损伤后诱导产生的新型肽，它们非常有趣。
