Esber E, DiNicola W, Movassaghi N, Leikin S
Pediatrics. 1975 Nov;56(5):788-92.
B and T lymphocyte surface receptors were studied in the bone marrow and peripheral blood of 16 patients with childhood acute lymphocytic leukemia. T cell surface receptors were identified on the blasts of one patient. Increased percentages of T or B cell surface receptors were not found in the bone marrow of the other 15 patients. There was a negative correlation between the percentage of pathologic cells in the peripheral blood and the percentage of cells with T and B surface receptors. The results of this study indicate that childhood acute lymphocytic leukemia is a heterogeneous disease in terms of lymphocyte surface receptors and that the pathologic cells of the majority of patients with this disease cannot be identified as being of thymic or non-thymic origin.
对16例儿童急性淋巴细胞白血病患者的骨髓和外周血中的B和T淋巴细胞表面受体进行了研究。在1例患者的原始细胞上鉴定出了T细胞表面受体。在其他15例患者的骨髓中未发现T或B细胞表面受体百分比增加。外周血中病理细胞的百分比与具有T和B表面受体的细胞百分比之间呈负相关。本研究结果表明，儿童急性淋巴细胞白血病在淋巴细胞表面受体方面是一种异质性疾病，并且该疾病大多数患者的病理细胞不能被确定为胸腺来源或非胸腺来源。
