某些吡唑并[3,4-d]嘧啶衍生物的合成、DNA结合及抗病毒活性
Synthesis, DNA-binding, and antiviral activity of certain pyrazolo[3,4-d]pyrimidine derivatives.
作者信息
el-Bendary E R, Badria F A
机构信息
Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
出版信息
Arch Pharm (Weinheim). 2000 Apr;333(4):99-103. doi: 10.1002/(sici)1521-4184(20004)333:4<99::aid-ardp99>3.0.co;2-o.
Some new pyrazolo[3,4-d]pyrimidine derivatives have been prepared and tested for their antiviral and DNA-binding activities. Compounds 4, 5, and 6 showed high binding affinity to DNA at concentrations of 19, 27, and 28 micrograms/ml, respectively. On the other hand, compounds 6 and 10 reduced the number of viral plaques of Herpes simplex type-1 (HSV-1) by 66 and 41%, respectively. The detailed synthesis and spectroscopic and biological data are reported.
已经制备了一些新型吡唑并[3,4 - d]嘧啶衍生物，并对其抗病毒和DNA结合活性进行了测试。化合物4、5和6分别在浓度为19、27和28微克/毫升时对DNA表现出高结合亲和力。另一方面，化合物6和10分别使单纯疱疹病毒1型（HSV - 1）的病毒蚀斑数量减少了66%和41%。报道了详细的合成、光谱和生物学数据。
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