Okamura T, Kitamura A, Moriyama Y, Imano H, Sato S, Terao A, Naito Y, Nakagawa Y, Kiyama M, Tamura Y, Iida M, Suzuki H, Komachi Y
Department of Epidemiology and Mass Examination for Cardiovascular Diseases, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
J Cardiovasc Risk. 1999 Dec;6(6):371-7. doi: 10.1177/204748739900600603.
Results of some epidemiologic studies in Western countries have clarified that hyperhomocysteinemia is a plausible risk factor for atherosclerotic vascular disease, but its role in Japanese communities is not known.
A community-based cross-sectional design.
We performed a cross-sectional study of 474 elderly men aged 60-74 years in two Japanese rural communities (Noichi in southwestern Japan and Ikawa in northeastern Japan). We examined the association between plasma concentrations of homocysteine and the maximum intima-media thickness (assessed by ultrasonography).
The prevalence of thickening was 10.7% for the lowest tertile of homocysteine level and 21.1% for the highest tertile. For the subjects without hypertension, the odds ratio for having carotid intima-media thickening was 5.8; it was significantly higher for the highest tertile of homocysteine level than it was for the lowest after adjusting for age, hypercholesterolemia, hypoalphalipoproteinemia, diabetes, and smoking by using a multiple logistic regression model. However, its correlation was not evident for those with hypertension.
High levels of plasma homocysteine are correlated to extracranial carotid artery atherosclerosis in elderly men without hypertension in Japanese rural communities.
西方国家一些流行病学研究结果已明确，高同型半胱氨酸血症是动脉粥样硬化性血管疾病一个可能的危险因素，但在日本人群中的作用尚不清楚。
基于社区的横断面设计。
我们对日本两个农村社区（日本西南部的野市和日本东北部的石川）的474名60 - 74岁老年男性进行了横断面研究。我们检测了同型半胱氨酸血浆浓度与最大内膜中层厚度（通过超声检查评估）之间的关联。
同型半胱氨酸水平最低三分位数组的增厚患病率为10.7%，最高三分位数组为21.1%。对于无高血压的受试者，颈动脉内膜中层增厚的比值比为5.8；在使用多元逻辑回归模型校正年龄、高胆固醇血症、低α脂蛋白血症、糖尿病和吸烟因素后，同型半胱氨酸水平最高三分位数组的比值比显著高于最低三分位数组。然而，对于有高血压的受试者，其相关性不明显。
在日本农村社区，血浆同型半胱氨酸水平升高与无高血压老年男性的颅外颈动脉粥样硬化相关。
