Chun J, Weiner J A, Fukushima N, Contos J J, Zhang G, Kimura Y, Dubin A, Ishii I, Hecht J H, Akita C, Kaushal D
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla 92093-0636, USA.
Ann N Y Acad Sci. 2000 Apr;905:110-7. doi: 10.1111/j.1749-6632.2000.tb06543.x.
Identification of the first lysophospholipid receptor, LPA1/Vzg-1, cloned by way of neurobiological analyses on the embryonic cerebral cortex, has led to the realization and demonstration that there exist multiple, homologous LP receptors, including those encoded by a number of orphan receptor genes known as "Edg," all of which are members of the G-protein-coupled receptor (GPCR) superfamily. These receptors interact with apparent high affinity for lysophosphatidic acid (LPA) or sphingosine-1-phosphate (S1P or SPP), and are referred to based upon their functional identity as lysophospholipid receptors: LPA and LPB receptors, respectively, with the expectation that additional subgroups will be identified (i.e., LPC, etc.). Here an update is provided on insights gained from analyses of these receptor genes as they relate to the nervous system, particularly the cerebral cortex, and myelinating cells (oligodendrocytes and Schwann cells).
通过对胚胎大脑皮层进行神经生物学分析，首次克隆出溶血磷脂受体LPA1/Vzg-1，这使人们认识到并证明存在多种同源的溶血磷脂受体，包括一些被称为“Edg”的孤儿受体基因所编码的受体，它们均为G蛋白偶联受体（GPCR）超家族的成员。这些受体对溶血磷脂酸（LPA）或鞘氨醇-1-磷酸（S1P或SPP）具有明显的高亲和力，并根据其功能特性分别被称为溶血磷脂受体：LPA受体和LPB受体，预计还会鉴定出其他亚组（如LPC等）。本文提供了关于这些受体基因分析所得见解的最新情况，这些见解与神经系统，特别是大脑皮层和髓鞘形成细胞（少突胶质细胞和施万细胞）相关。
