Fukushima Nobuyuki, Ye Xiaoqin, Chun Jerold
Department of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Neuroscientist. 2002 Dec;8(6):540-50. doi: 10.1177/1073858402238513.
Lysophosphatidic acid (LPA), a growth factor-like lysophospholipid, induces diverse cellular responses. The identification of the first LPA receptor gene, through studies of neuroproliferative regions within the embryonic cerebral cortex, has led to the classification of a family of at least eight lysophospholipid receptors with diverse roles in organismal development and function. A growing body of literature has identified roles for LPA signaling under physiological and pathological conditions, particularly within the developing nervous system. Here the authors review features of the LPA receptor family and cellular responses of nervous system-derived cells, and discuss developmental and pathological roles for LPA signaling in the nervous system.
溶血磷脂酸（LPA）是一种类似生长因子的溶血磷脂，可诱导多种细胞反应。通过对胚胎大脑皮质内神经增殖区域的研究，首个LPA受体基因得以鉴定，这促使了一个由至少8种溶血磷脂受体组成的家族的分类，这些受体在机体发育和功能中具有不同作用。越来越多的文献已确定了LPA信号在生理和病理条件下的作用，尤其是在发育中的神经系统中。本文作者综述了LPA受体家族的特征以及神经系统衍生细胞的细胞反应，并讨论了LPA信号在神经系统中的发育和病理作用。
