Swaminathan S, Nandini K S, Hanna L E, Somu N, Narayanan P R, Barnes P F
Tuberculosis Research Center, Chennai, 600 031, India. Center for pulmonary and Infectious Disease Control, University of Texas Health Center at Tyler, Texas, USA.
Indian Pediatr. 2000 May;37(5):489-95.
Tuberculosis is associated with both qualitative and quantitative defects in the cell mediated immune response. The changes that occur in the lymphocyte profile in blood in children with tuberculosis are not well understood.
Prospective study.
Referral hospitals.
Lymphocyte subpopulations were determined by flow cytometry in 17 healthy tuberculin positive children, in 22 children with newly diagnosed pulmonary tuberculosis and in 8 of these children after antituberculosis therapy.
Absolute numbers and percentages of CD3+ and CD4+ T cells were reduced in children with tuberculosis, compared to controls. CD4+ counts increased significantly following antituberculosis treatment, compared to baseline values. In contrast, the proportion of T cells expressing the gdT cell receptor was similar in tuberculosis patients and controls.
Children with tuberculosis have a systemic decrease in the proportion and number of CD3+ and CD4+ T cells which reverses during therapy.
结核病与细胞介导免疫反应的质量和数量缺陷均有关联。结核病患儿血液中淋巴细胞谱的变化尚未得到充分了解。
前瞻性研究。
转诊医院。
通过流式细胞术测定了17名健康结核菌素阳性儿童、22名新诊断为肺结核的儿童以及其中8名儿童在抗结核治疗后的淋巴细胞亚群。
与对照组相比，结核病患儿的CD3+和CD4+ T细胞的绝对数量和百分比均降低。与基线值相比，抗结核治疗后CD4+计数显著增加。相比之下，表达γδT细胞受体的T细胞比例在结核病患者和对照组中相似。
结核病患儿的CD3+和CD4+ T细胞比例和数量出现全身性下降，治疗期间这种情况会逆转。
