针对H-2复合体K和D位点产物的同种抗血清对三硝基苯基衍生化靶细胞的细胞介导细胞溶解作用的抑制。
Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.
作者信息
Burakoff S J, Germain R N, Dorf M E, Benacerrah B
出版信息
Proc Natl Acad Sci U S A. 1976 Feb;73(2):625-9. doi: 10.1073/pnas.73.2.625.
Abstract
The role of the products of the K and D loci of the H-2 complex as target antigens for cytotoxic T cells generated to modified syngeneic cells has been investigated. Spleen cells, when cocultured with trinitrophenyl-derivatized syngeneic cells, generate cytolytic T cells that lyse most effectively tumor or spleen targets that are trinitrophenyl-derivatized and H-2 identical to the sensitizing cell. Cytolysis is inhibited by alloantisera to the K and/or D specificities of the target cells and by anti-dinitrophenyl antisera. Cytolic cells generated in this manner are also able to lyse, though less efficiently, trinitrophenyl-derivatized tumor and spleen targets that do not share products of the K and D loci with the sensitizing cell, and this cytolysis is also blocked by alloantisera directed to the H-2 serological specificities of such targets.
摘要
已经研究了H-2复合体的K和D位点产物作为针对由经修饰的同基因细胞产生的细胞毒性T细胞的靶抗原的作用。脾细胞与三硝基苯基衍生的同基因细胞共培养时，会产生溶细胞性T细胞，这些细胞最有效地裂解经三硝基苯基衍生且H-2与致敏细胞相同的肿瘤或脾靶细胞。细胞溶解受到针对靶细胞K和/或D特异性的同种抗血清以及抗二硝基苯基抗血清的抑制。以这种方式产生的溶细胞性细胞也能够裂解（尽管效率较低）与致敏细胞不共享K和D位点产物的经三硝基苯基衍生的肿瘤和脾靶细胞，并且这种细胞溶解也被针对此类靶细胞的H-2血清学特异性的同种抗血清所阻断。
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Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.针对H-2复合体K和D位点产物的同种抗血清对三硝基苯基衍生化靶细胞的细胞介导细胞溶解作用的抑制。
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本文引用的文献
1
Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.对三硝基苯基修饰的同基因淋巴细胞的细胞介导细胞毒性。
Eur J Immunol. 1974 Aug;4(8):527-33. doi: 10.1002/eji.1830040802.
2
Cell-mediated cell lysis in vitro: genetic control of killer cell production and target specificities in the mouse.体外细胞介导的细胞裂解：小鼠中杀伤细胞产生和靶细胞特异性的遗传控制。
Eur J Immunol. 1974 May;4(5):378-87. doi: 10.1002/eji.1830040514.
3
Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.细胞介导的细胞毒性、同种异体移植排斥反应和肿瘤免疫。
Adv Immunol. 1974;18:67-132. doi: 10.1016/s0065-2776(08)60308-9.
4
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.在同基因或半同种异体系统中淋巴细胞性脉络丛脑膜炎体外T细胞介导的细胞毒性的限制。
Nature. 1974 Apr 19;248(5450):701-2. doi: 10.1038/248701a0.
5
The H-2 model for the major histocompatibility systems.主要组织相容性系统的H-2模型。
Transplant Rev. 1971;6:3-29. doi: 10.1111/j.1600-065x.1971.tb00457.x.
6
Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Confirmation of genetic control of response to trinitrophenyl-modified H-2 antigens by the use of anti-H-2 and anti-Ia antibodies.三硝基苯基修饰的自体淋巴细胞的细胞介导淋巴细胞溶解。通过使用抗H-2和抗Ia抗体证实对三硝基苯基修饰的H-2抗原反应的遗传控制。
J Exp Med. 1976 Jan 1;143(1):211-7. doi: 10.1084/jem.143.1.211.
7
Specific and nonspecific antitumor immunity. I. Description of an in vitro assay based on inhibition of DNA synthesis in tumor cells.特异性和非特异性抗肿瘤免疫。I. 一种基于抑制肿瘤细胞DNA合成的体外检测方法的描述。
J Natl Cancer Inst. 1975 Mar;54(3):697-708.
8
Target cell-dependent T cell-mediated lysis of vaccinia virus-infected cells.靶细胞依赖性T细胞介导的痘苗病毒感染细胞的裂解。
Eur J Immunol. 1975 Apr;5(4):245-51. doi: 10.1002/eji.1830050405.
9
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10
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