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1
Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.针对H-2复合体K和D位点产物的同种抗血清对三硝基苯基衍生化靶细胞的细胞介导细胞溶解作用的抑制。
Proc Natl Acad Sci U S A. 1976 Feb;73(2):625-9. doi: 10.1073/pnas.73.2.625.
2
Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells.针对同基因三硝基苯（TNP）脾细胞产生的细胞毒性T淋巴细胞对三硝基苯衍生化的H-2不相容靶细胞的交叉反应性裂解。
J Exp Med. 1976 Dec 1;144(6):1609-20. doi: 10.1084/jem.144.6.1609.
3
Inhibition of T-lymphocyte-mediated tumor-specific lysis by alloantisera directed against the H-2 serological specificities of the tumor.针对肿瘤H-2血清学特异性的同种抗血清对T淋巴细胞介导的肿瘤特异性溶解的抑制作用。
J Exp Med. 1975 Oct 1;142(4):1023-8. doi: 10.1084/jem.142.4.1023.
4
Specificity of rat xenogeneic cell-mediated cytolysis for the products of the K and D loci of the mouse H-2 complex.大鼠异种细胞介导的细胞溶解对小鼠H-2复合体K和D位点产物的特异性
J Immunol. 1977 May;118(5):1795-8.
5
On the role of the H-2 histocompatibility complex in determining the specificity of cytotoxic effector cells sensitized against syngeneic trinitrophenyl-modified targets.关于H-2组织相容性复合体在确定针对同基因三硝基苯基修饰靶标的细胞毒性效应细胞特异性中的作用。
J Exp Med. 1975 Aug 1;142(2):403-18. doi: 10.1084/jem.142.2.403.
6
Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells.对同种异体刺激细胞具有特异性的溶细胞性胸腺来源淋巴细胞与化学修饰的同基因细胞发生交叉反应。
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1229-33. doi: 10.1073/pnas.74.3.1229.
7
Cytotoxic T lymphocytes induced against allogeneic I-region determinants react with Ia molecules on trinitrophenyl-conjugated syngeneic target cells.针对同种异体I区决定簇诱导产生的细胞毒性T淋巴细胞与三硝基苯偶联的同基因靶细胞上的Ia分子发生反应。
J Exp Med. 1977 Aug 1;146(2):623-8. doi: 10.1084/jem.146.2.623.
8
Cytotoxic T lymphocytes specific for I region determinants do not require interactions with H-2K or D gene products.针对I区决定簇的细胞毒性T淋巴细胞不需要与H-2K或D基因产物相互作用。
J Exp Med. 1977 May 1;145(5):1387-92. doi: 10.1084/jem.145.5.1387.
9
Relationship between trinitrophenyl and H-2 antigens on trinitrophenyl-modified spleen cells. I. H-2 antigens on cells treated with trinitrobenzene sulfonic acid are derivatized.三硝基苯基修饰的脾细胞上三硝基苯基与H-2抗原的关系。I. 用三硝基苯磺酸处理的细胞上的H-2抗原被衍生化。
J Immunol. 1977 Mar;118(3):797-802.
10
Exclusive involvement of H-2Db or H-2Kd product in the interaction between T-killer lymphocytes and syngeneic H-2b or H-2d viral lymphomas.H-2Db或H-2Kd产物在杀伤性T淋巴细胞与同基因H-2b或H-2d病毒性淋巴瘤之间相互作用中的特异性参与。
J Exp Med. 1977 Oct 1;146(4):909-22. doi: 10.1084/jem.146.4.909.

引用本文的文献

1
Secondary cytolytic T lymphocyte stimulation by purified H-2Kk in liposomes.脂质体中纯化的H-2Kk对细胞溶解性T淋巴细胞的二次刺激
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2488-92. doi: 10.1073/pnas.78.4.2488.
2
Type-specific reovirus antiserum blocks the cytotoxic T-cell-target cell interaction: evidence for the association of the viral hemagglutinin of a nonenveloped virus with the cell surface.型特异性呼肠孤病毒抗血清阻断细胞毒性T细胞与靶细胞的相互作用：无包膜病毒的病毒血凝素与细胞表面相关的证据。
Infect Immun. 1981 Feb;31(2):646-9. doi: 10.1128/iai.31.2.646-649.1981.
3
Cellular interactions in the generation of cytolytic T lymphocyte responses: role of Ia-positive splenic adherent cells in presentation in H-2 antigen.细胞毒性T淋巴细胞反应产生中的细胞间相互作用：Ia阳性脾黏附细胞在H-2抗原呈递中的作用。
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6091-5. doi: 10.1073/pnas.77.10.6091.
4
Target-cell recognition by cloned lines of influenza virus-specific cytotoxic T lymphocytes. Selective inhibition by a monoclonal H-2-specific antibody.流感病毒特异性细胞毒性T淋巴细胞克隆系对靶细胞的识别。单克隆H-2特异性抗体的选择性抑制作用。
Immunogenetics. 1982 Jan;15(1):41-52. doi: 10.1007/BF00375501.
5
T lymphocyte-mediated suppression of myeloma function in vitro. III. Regulation of antibody production in hybrid myeloma cells by T lymphocytes.T淋巴细胞在体外对骨髓瘤功能的介导抑制作用。III. T淋巴细胞对杂交骨髓瘤细胞中抗体产生的调节。
J Exp Med. 1980 Oct 1;152(4):969-78. doi: 10.1084/jem.152.4.969.
6
T lymphocyte-mediated suppression of myeloma function in vitro. II. Evidence for regulation of hapten-binding myelomas by syngeneic hapten-specific cytolytic T lymphocytes.T淋巴细胞在体外介导的骨髓瘤功能抑制。II. 同基因半抗原特异性细胞毒性T淋巴细胞对半抗原结合骨髓瘤调节作用的证据。
J Exp Med. 1980 Aug 1;152(2):306-23. doi: 10.1084/jem.152.2.306.
7
Generation of cytolytic T lymphocytes in thymectomized, irradiated, and bone marrow-reconstituted mice.在胸腺切除、照射并进行骨髓重建的小鼠中细胞毒性T淋巴细胞的产生。
J Exp Med. 1982 Sep 1;156(3):844-59. doi: 10.1084/jem.156.3.844.
8
Inhibition of antiskin allograft immunity induced by infusions with photoinactivated effector T lymphocytes (PET cells).通过输注光灭活效应T淋巴细胞（PET细胞）诱导的抗皮肤同种异体移植免疫的抑制作用。
Yale J Biol Med. 1989 Nov-Dec;62(6):595-609.
9
Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells.针对同基因三硝基苯（TNP）脾细胞产生的细胞毒性T淋巴细胞对三硝基苯衍生化的H-2不相容靶细胞的交叉反应性裂解。
J Exp Med. 1976 Dec 1;144(6):1609-20. doi: 10.1084/jem.144.6.1609.
10
Soluble factors in tolerance and contact sensitivity to 2,4-dinitrofluorobenzene in mice. III. Histocompatibility antigens associated with the hapten dinitrophenol serve as target molecules on 2,4-dinitrofluorobenzene-immune T cells for soluble suppressor factor.小鼠对2,4-二硝基氟苯耐受性和接触敏感性中的可溶性因子。III. 与半抗原二硝基苯酚相关的组织相容性抗原作为2,4-二硝基氟苯免疫T细胞上可溶性抑制因子的靶分子。
J Exp Med. 1979 Dec 1;150(6):1432-47. doi: 10.1084/jem.150.6.1432.

本文引用的文献

1
Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.对三硝基苯基修饰的同基因淋巴细胞的细胞介导细胞毒性。
Eur J Immunol. 1974 Aug;4(8):527-33. doi: 10.1002/eji.1830040802.
2
Cell-mediated cell lysis in vitro: genetic control of killer cell production and target specificities in the mouse.体外细胞介导的细胞裂解：小鼠中杀伤细胞产生和靶细胞特异性的遗传控制。
Eur J Immunol. 1974 May;4(5):378-87. doi: 10.1002/eji.1830040514.
3
Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.细胞介导的细胞毒性、同种异体移植排斥反应和肿瘤免疫。
Adv Immunol. 1974;18:67-132. doi: 10.1016/s0065-2776(08)60308-9.
4
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.在同基因或半同种异体系统中淋巴细胞性脉络丛脑膜炎体外T细胞介导的细胞毒性的限制。
Nature. 1974 Apr 19;248(5450):701-2. doi: 10.1038/248701a0.
5
The H-2 model for the major histocompatibility systems.主要组织相容性系统的H-2模型。
Transplant Rev. 1971;6:3-29. doi: 10.1111/j.1600-065x.1971.tb00457.x.
6
Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Confirmation of genetic control of response to trinitrophenyl-modified H-2 antigens by the use of anti-H-2 and anti-Ia antibodies.三硝基苯基修饰的自体淋巴细胞的细胞介导淋巴细胞溶解。通过使用抗H-2和抗Ia抗体证实对三硝基苯基修饰的H-2抗原反应的遗传控制。
J Exp Med. 1976 Jan 1;143(1):211-7. doi: 10.1084/jem.143.1.211.
7
Specific and nonspecific antitumor immunity. I. Description of an in vitro assay based on inhibition of DNA synthesis in tumor cells.特异性和非特异性抗肿瘤免疫。I. 一种基于抑制肿瘤细胞DNA合成的体外检测方法的描述。
J Natl Cancer Inst. 1975 Mar;54(3):697-708.
8
Target cell-dependent T cell-mediated lysis of vaccinia virus-infected cells.靶细胞依赖性T细胞介导的痘苗病毒感染细胞的裂解。
Eur J Immunol. 1975 Apr;5(4):245-51. doi: 10.1002/eji.1830050405.
9
Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier.细胞毒性T细胞检测到的相互作用抗原，以主要组织相容性复合体作为修饰因子。
Nature. 1975 Jul 31;256(5516):419-21. doi: 10.1038/256419a0.
10
Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus.由T细胞介导并受感染痘苗病毒的靶细胞的H-2抗原限制的细胞溶解作用。
Nature. 1975 Jun 12;255(5509):552-4. doi: 10.1038/255552a0.

针对H-2复合体K和D位点产物的同种抗血清对三硝基苯基衍生化靶细胞的细胞介导细胞溶解作用的抑制。

Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.

作者信息

Burakoff S J, Germain R N, Dorf M E, Benacerrah B

出版信息

Proc Natl Acad Sci U S A. 1976 Feb;73(2):625-9. doi: 10.1073/pnas.73.2.625.

DOI:10.1073/pnas.73.2.625
PMID:1082140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC335964/
Abstract

The role of the products of the K and D loci of the H-2 complex as target antigens for cytotoxic T cells generated to modified syngeneic cells has been investigated. Spleen cells, when cocultured with trinitrophenyl-derivatized syngeneic cells, generate cytolytic T cells that lyse most effectively tumor or spleen targets that are trinitrophenyl-derivatized and H-2 identical to the sensitizing cell. Cytolysis is inhibited by alloantisera to the K and/or D specificities of the target cells and by anti-dinitrophenyl antisera. Cytolic cells generated in this manner are also able to lyse, though less efficiently, trinitrophenyl-derivatized tumor and spleen targets that do not share products of the K and D loci with the sensitizing cell, and this cytolysis is also blocked by alloantisera directed to the H-2 serological specificities of such targets.

摘要

已经研究了H-2复合体的K和D位点产物作为针对由经修饰的同基因细胞产生的细胞毒性T细胞的靶抗原的作用。脾细胞与三硝基苯基衍生的同基因细胞共培养时，会产生溶细胞性T细胞，这些细胞最有效地裂解经三硝基苯基衍生且H-2与致敏细胞相同的肿瘤或脾靶细胞。细胞溶解受到针对靶细胞K和/或D特异性的同种抗血清以及抗二硝基苯基抗血清的抑制。以这种方式产生的溶细胞性细胞也能够裂解（尽管效率较低）与致敏细胞不共享K和D位点产物的经三硝基苯基衍生的肿瘤和脾靶细胞，并且这种细胞溶解也被针对此类靶细胞的H-2血清学特异性的同种抗血清所阻断。