脑脊液中的细胞骨架蛋白可区分额颞叶痴呆与阿尔茨海默病。

Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD.

作者信息

Sjögren M, Rosengren L, Minthon L, Davidsson P, Blennow K, Wallin A

机构信息

Institute of Clinical Neuroscience, Göteborg University, Sweden.

出版信息

Neurology. 2000 May 23;54(10):1960-4. doi: 10.1212/wnl.54.10.1960.

DOI:10.1212/wnl.54.10.1960

PMID:10822437

Abstract

OBJECTIVE AND BACKGROUND

To investigate the CSF levels of tau and the light neurofilament protein (NFL) in patients with frontotemporal dementia (FTD) and other common dementia disorders as well as normal control subjects. Both proteins have been implicated in the pathophysiology of FTD.

METHODS

CSF levels of tau and NFL were investigated in 18 patients with FTD, 21 patients with early-onset AD (EAD), 21 patients with late-onset AD (LAD), and 18 age-matched control subjects.

RESULTS

Mean +/- SD CSF NFL levels were increased in patients with FTD (1442 +/- 1183 pg/mL; p < 0.05) and LAD (1006 +/- 727 pg/mL; p < 0.001) compared with control subjects (241 +/- 166 pg/mL) and in LAD compared with EAD (498 +/- 236 pg/mL; p < 0.05), and tended to be increased in FTD compared with EAD. CSF tau levels were increased in EAD (751 +/- 394 pg/mL; p < 0.01) and LAD (699 +/- 319 pg/mL; p < 0.01) compared with control subjects (375 +/- 170 pg/mL), and in EAD (p < 0.001) and LAD (p < 0. 01) compared with FTD (354 +/- 140 pg/mL). CSF NFL correlated positively with degree of cognitive impairment in FTD (r = 0.59; p < 0.05) and LAD (r = 0.61; p < 0.01). No significant differences were found in CSF NFL or CSF tau when comparing patients who did and did not possess the APOE-epsilon4 allele within each diagnostic group.

CONCLUSION

The results suggest a differential involvement of these cytoskeleton proteins in FTD and EAD, with NFL primarily involved in the pathophysiology of FTD and tau in that of EAD. The increase in CSF NFL found in LAD might reflect the white-matter degeneration found in a proportion of LAD cases.

摘要

目的与背景

研究额颞叶痴呆（FTD）患者、其他常见痴呆症患者以及正常对照者脑脊液中tau蛋白和轻链神经丝蛋白（NFL）的水平。这两种蛋白均与FTD的病理生理学有关。

方法

检测了18例FTD患者、21例早发性阿尔茨海默病（EAD）患者、21例晚发性阿尔茨海默病（LAD）患者以及18例年龄匹配的对照者脑脊液中tau蛋白和NFL的水平。

结果

与对照者（241±166 pg/mL）相比，FTD患者（1442±1183 pg/mL；p<0.05）和LAD患者（1006±727 pg/mL；p<0.001）的脑脊液NFL平均水平升高，与EAD患者相比，LAD患者的脑脊液NFL平均水平也升高（498±236 pg/mL；p<0.05），FTD患者的脑脊液NFL平均水平与EAD患者相比有升高趋势。与对照者（375±170 pg/mL）相比，EAD患者（751±394 pg/mL；p<0.01）和LAD患者（699±319 pg/mL；p<0.01）的脑脊液tau水平升高，与FTD患者（354±140 pg/mL）相比，EAD患者（p<0.001）和LAD患者（p<0.01）的脑脊液tau水平也升高。在FTD患者（r = 0.59；p<0.05）和LAD患者（r = 0.61；p<0.01）中，脑脊液NFL水平与认知障碍程度呈正相关。在每个诊断组中，比较携带和未携带APOE-ε4等位基因的患者，脑脊液NFL或脑脊液tau水平均未发现显著差异。