Sieśkiewicz A, Rogowski M, Gindzieńska E
Klinika Otolaryngologii AM w Białymstoku.
Otolaryngol Pol. 2000;54(1):61-6.
The group of patients suffering from tinnitus was treated with intravenous Xylocaine. Ten consecutive doses of Xylocaine (2 mg/kg b.m.) were administered during a period of ten days. Changes of amplitudes of TEOAE in relation to tinnitus suppression was assessed. In 91.5% of cases we observed correlation between amplitude changes and complaint abatement. Both amplitude changes and the time of tinnitus suppression increased after ten days of treatment in comparison with single dose of Xylocaine. The differences of amplitude variations between tinnitus and non tinnitus ear group was statistically significant (Wilcoxon test p < 0.05). The treatment with Xylocaine was considered to be the beginning of long-term procedure aimed at causing habituation of tinnitus in patients conscience (TRT).
耳鸣患者组接受了静脉注射利多卡因治疗。在十天的时间内连续给予十剂利多卡因（2毫克/千克体重）。评估了瞬态耳声发射（TEOAE）振幅与耳鸣抑制之间的变化关系。在91.5%的病例中，我们观察到振幅变化与症状减轻之间存在相关性。与单次注射利多卡因相比，治疗十天后，振幅变化和耳鸣抑制时间均有所增加。耳鸣组和非耳鸣组的振幅变化差异具有统计学意义（威尔科克森检验，p < 0.05）。利多卡因治疗被认为是旨在使患者意识中耳鸣习惯化的长期程序（耳鸣再训练疗法，TRT）的开始。
