Yamanaka E, Gyo K, Saiki T, Yanagihara N
Nihon Jibiinkoka Gakkai Kaiho. 1989 Apr;92(4):566-73. doi: 10.3950/jibiinkoka.92.566.
One hundreds and forty-nine patients (221 ears) suffering from tinnitus were treated by an intravenous administration of Xylocaine. Xylocaine, 1mg per kg, was administered once a week. The immediate effect of Xylocaine on tinnitus was evaluated subjectively for all the patients. The long term effect in 57 patients who received Xylocaine administration more than 12 times was also analyzed. The results can be summarized as follows. 1. Short and long term relief of tinnitus was obtained in 165 of 221 ears (74.7%) and in 35 of 57 cases (61.4%), respectively. 2. This therapy was more effective in old patients and in the patients with low pitch tinnitus, or with positive residual inhibition. 3. The numbers of the effective cases increased after the 8th time administration of Xylocaine. Thus we recommend the Xylocaine administration at least 8 times. 4. The results of the loudness balance test were not correlated with the change of the subjective improvements. 5. The suppressive effect of tinnitus by injecting saline solution intravenously was recognized in 24 of 73 cases. At present, repeated administration of Xylocaine would be one of the most significant therapies of tinnitus.
149例（221耳）耳鸣患者接受了静脉注射利多卡因治疗。利多卡因剂量为每千克1毫克，每周给药1次。对所有患者主观评估利多卡因对耳鸣的即时疗效。还分析了57例接受利多卡因注射超过12次患者的长期疗效。结果总结如下：1. 221耳中的165耳（74.7%）和57例中的35例（61.4%）分别获得了耳鸣的短期和长期缓解。2. 该疗法对老年患者、低音调耳鸣患者或有阳性残余抑制的患者更有效。3. 利多卡因第8次给药后有效病例数增加。因此，我们建议至少给药8次。4. 响度平衡测试结果与主观改善变化无关。5. 73例中有24例通过静脉注射生理盐水可观察到耳鸣抑制效果。目前，重复注射利多卡因是耳鸣最重要的治疗方法之一。
