利多卡因注射对耳鸣患者耳声发射的影响。

Effect of lidocaine injection of EOAE in patients with tinnitus.

作者信息

Haginomori S, Makimoto K, Araki M, Kawakami M, Takahashi H

机构信息

Department of Otolaryngology, Osaka Medical College, Takatsuki, Japan.

出版信息

Acta Otolaryngol. 1995 Jul;115(4):488-92. doi: 10.3109/00016489509139353.

DOI:10.3109/00016489509139353

PMID:7572122

Abstract

In the present study, evoked otoacoustic emissions (EOAEs) were measured in 30 patients with tinnitus before and after intravenous lidocaine injection (1 mg/kg). For EOAE recordings, 1 kHz tone burst stimuli were used. Intravenous lidocaine injection resulted in suppression of tinnitus in 22 (73%) ears, and changes of EOAE amplitude (increase or decrease) in 18 (60%) ears. Of the 18 ears with EOAE amplitude changes, tinnitus disappeared or decreased in 17 (94%) ears. In 12 ears without changes of EOAE amplitude, tinnitus was suppressed in only 5 (42%). Changes in latency were not detected in any of the ears. These results indicate that there is a relationship between the effect of lidocaine in tinnitus suppression and changes in cochlear micromechanics caused by lidocaine.

摘要

在本研究中，对30例耳鸣患者在静脉注射利多卡因（1mg/kg）前后测量了诱发耳声发射（EOAE）。进行EOAE记录时，使用了1kHz短纯音刺激。静脉注射利多卡因导致22只（73%）耳朵的耳鸣得到抑制，18只（60%）耳朵的EOAE幅度发生变化（增加或降低）。在18只EOAE幅度有变化的耳朵中，17只（94%）耳朵的耳鸣消失或减轻。在12只EOAE幅度无变化的耳朵中，只有5只（42%）耳朵的耳鸣得到抑制。所有耳朵均未检测到潜伏期变化。这些结果表明，利多卡因抑制耳鸣的效果与利多卡因引起的耳蜗微力学变化之间存在关联。