感染人类免疫缺陷病毒的儿童侵袭性肺炎球菌疾病周围的群特异性抗体水平。

Group-specific antibody levels surrounding invasive pneumococcal illness in children infected with human immunodeficiency virus.

作者信息

King J C, Borkowsky W, Mahidhara N, Madore D, Shapiro E D, Rutstein R M, Tan T Q, Farley J J, Dankner W M, Nachman S, Simoes E, Flynn P M, Clemens J, Hamilton R G

机构信息

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

出版信息

J Infect Dis. 2000 May;181(5):1817-21. doi: 10.1086/315441. Epub 2000 May 15.

DOI:10.1086/315441

PMID:10823792

Abstract

Pneumococcal antibody levels surrounding systemic pneumococcal illness (SPI) were measured in children infected with human immunodeficiency virus (HIV). Archived serum samples were collected from 28 HIV-infected children who had 34 cases of SPI, caused by pneumococcal groups 4, 6, 9, 14, 19, and 23. Serum samples collected within 23 weeks before and 13 weeks after the SPI were assayed by ELISA for antipneumococcal polysaccharide (PnPs) IgG antibody to 6 representative pneumococcal serotypes. There was a wide range (0. 16-30.80 microg/mL) of pre-SPI anti-PnPs antibody levels to the presumed infecting serotypes, with a geometric mean level of 0.83 microg/mL (n=34). Seventy-six percent of the antibody values were <2.0 microg/mL, and 95% were <5.0 microg/mL. Homologous seroresponses (>/=4-fold rise in anti-PnPs antibody) were detected in only 4 (27%) of 15 paired serum samples. Heterologous, noninfecting group seroresponses were detected frequently (72%) in the paired serum samples from these 4 homologous group seroresponders.

摘要

对感染人类免疫缺陷病毒（HIV）的儿童在全身性肺炎球菌疾病（SPI）发作前后的肺炎球菌抗体水平进行了测量。从28名感染HIV的儿童中收集了存档血清样本，这些儿童共出现34例由4、6、9、14、19和23型肺炎球菌引起的SPI。采用酶联免疫吸附测定（ELISA）法，检测SPI发作前23周内及发作后13周内收集的血清样本中针对6种代表性肺炎球菌血清型的抗肺炎球菌多糖（PnPs）IgG抗体。在SPI发作前，针对假定感染血清型的抗PnPs抗体水平范围很广（0.16 - 30.80μg/mL），几何平均水平为0.83μg/mL（n = 34）。76%的抗体值<2.0μg/mL，95%的抗体值<5.0μg/mL。在15对配对血清样本中，仅4例（27%）检测到同源血清反应（抗PnPs抗体升高≥4倍）。在这4例同源血清反应者的配对血清样本中，经常检测到异源、非感染组血清反应（72%）。