Lyytikäinen O, Autio T, Maijala R, Ruutu P, Honkanen-Buzalski T, Miettinen M, Hatakka M, Mikkola J, Anttila V J, Johansson T, Rantala L, Aalto T, Korkeala H, Siitonen A
Department of Infectious Disease Epidemiology, National Public Health Institute, FIN-00300 Helsinki, Finland. outi.lyytikainen@ktl. fi.
J Infect Dis. 2000 May;181(5):1838-41. doi: 10.1086/315453. Epub 2000 May 9.
In February 1999, an outbreak of listeriosis caused by Listeria monocytogenes serotype 3a occurred in Finland. All isolates were identical. The outbreak strain was first isolated in 1997 in dairy butter. This dairy began delivery to a tertiary care hospital (TCH) in June 1998. From June 1998 to April 1999, 25 case patients were identified (20 with sepsis, 4 with meningitis, and 1 with abscess; 6 patients died). Patients with the outbreak strain were more likely to have been admitted to the TCH than were patients with other strains of L. monocytogenes (60% vs. 8%; odds ratio, 17.3; 95% confidence interval, 2.8-136.8). Case patients admitted to the TCH had been hospitalized longer before cultures tested positive than had matched controls (median, 31 vs. 10 days; P=.008). An investigation found the outbreak strain in packaged butter served at the TCH and at the source dairy. Recall of the product ended the outbreak.
1999年2月，芬兰发生了由单核细胞增生李斯特菌3a血清型引起的李斯特菌病暴发。所有分离株均相同。暴发菌株于1997年首次在乳脂中分离出来。该乳品厂于1998年6月开始向一家三级护理医院（TCH）供货。从1998年6月到1999年4月，共确诊了25例病例（20例败血症、4例脑膜炎和1例脓肿；6例患者死亡）。与感染其他单核细胞增生李斯特菌菌株的患者相比，感染暴发菌株的患者更有可能入住TCH（60%对8%；比值比为17.3；95%置信区间为2.8 - 136.8）。入住TCH的病例患者在培养结果呈阳性之前住院时间比匹配的对照组更长（中位数分别为31天和10天；P = 0.008）。一项调查在TCH和源头乳品厂供应的包装黄油中发现了暴发菌株。召回该产品后疫情结束。
