Orchard G E
Dermatopathology Department, St John's Dermatology Centre, St Thomas' Hospital, London, England, UK.
Br J Biomed Sci. 1999;56(3):188-93.
The effect of melanin bleaching using permanganate/oxalate and dilute hydrogen peroxide on subsequent immunohistochemical staining of heavily pigmented melanocytic neoplasms is investigated. Permanganate/oxalate precluded the use of some antibodies but allowed much faster bleaching times, whereas dilute hydrogen peroxide enabled a full range of antibodies to be used, yet bleaching times were far longer. Each technique has advantages; however, the choice of method should be determined by the nature of the information needed to make a diagnosis and the speed at which a report is required.
研究了使用高锰酸盐/草酸盐和稀过氧化氢进行黑色素漂白对重度色素沉着黑素细胞肿瘤后续免疫组织化学染色的影响。高锰酸盐/草酸盐排除了某些抗体的使用，但漂白时间快得多，而稀过氧化氢则能使用所有抗体，不过漂白时间长得多。每种技术都有其优点；然而，方法的选择应根据做出诊断所需信息的性质以及报告所需的速度来确定。
