Shimoni Z, Pitlik S, Leibovici L, Samra Z, Konigsberger H, Drucker M, Agmon V, Ashkenazi S, Weinberger M
Department of Internal Medicine C, Rabin Medical Center, Petach Tikva, Israel.
Clin Infect Dis. 1999 Apr;28(4):822-7. doi: 10.1086/515186.
In a retrospective study, 80 episodes of nontyphoid salmonella (NTS) bacteremia in children were compared with 55 episodes in adults over a 10-year period. The study disclosed major differences in the predisposition, clinical presentation, and outcome as well as the microbiology of NTS bacteremia in relation to age. Adults were more likely than children to have predisposing diseases (95% vs. 15%, respectively; P < .0001) and to receive prior medications (95% vs. 23%, respectively; P < .0001), particularly immunosuppressive agents (58% vs. 5%, respectively; P < .0001). In most adults (67%), NTS infection presented as a primary bacteremia and was associated with a high incidence of extraintestinal organ involvement (34%) and a high mortality rate (33%). In children, NTS bacteremia was usually secondary to gastroenteritis (75%) and caused no fatalities. Although group D Salmonella (78%) and the serovar Salmonella enteritidis were the predominant isolates from adults, the emergence of infections due to group C Salmonella (46%) and the serovar Salmonella virchow in children was noted.
在一项回顾性研究中，对10年间儿童的80例非伤寒沙门菌（NTS）菌血症发作与成人的55例发作进行了比较。该研究揭示了NTS菌血症在易感性、临床表现、结局以及微生物学方面与年龄相关的主要差异。成人比儿童更易患有易感疾病（分别为95%和15%；P <.0001），且更常接受过先前的药物治疗（分别为95%和23%；P <.0001），尤其是免疫抑制剂（分别为58%和5%；P <.0001）。在大多数成人中（67%），NTS感染表现为原发性菌血症，并伴有肠外器官受累的高发生率（34%）和高死亡率（33%）。在儿童中，NTS菌血症通常继发于胃肠炎（75%），且无死亡病例。尽管D群沙门菌（78%）和肠炎沙门菌血清型是成人的主要分离菌株，但注意到儿童中C群沙门菌（46%）和维尔肖沙门菌血清型引起的感染有所增加。
