Valls-Solé J, Veciana M, Serra J, Cruccu G, Romaniello A
Institut d'Investigacio Biomedica August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
Neurosci Lett. 2000 Jun 2;286(2):79-82. doi: 10.1016/s0304-3940(00)01085-5.
The subcortical integrative effects of laser-induced activation of pain ascending tracts were examined in 11 healthy volunteers, aged 22-52 years. Subjects underwent either CO2 laser stimulation at the dorsum of the hand, electrical stimulation of digital nerves at the 3rd finger, or mechanical taps to the first dorsal interosseous space, preceding a blink reflex elicited by a supraorbital nerve electrical stimulus. The percentage inhibition induced in the R2 response of the blink reflex was similar for the three different stimulus modalities, but occurred at a different time interval. Compared to control trials, the R2 response of the test trials was a mean of 23.1% at the interval of 250 ms with laser stimuli, 17.4% at the interval of 100 ms with electrical stimuli to the 3rd finger, and 20.6% at the interval of 90 ms with a mechanical tap to the 1st interosseous space. Activation of pain receptors induces prepulse inhibition of the blink reflex at a delay corresponding to a slowly conducting pathway. The percentage inhibition is similar to that observed with other somatosensory inputs.
在11名年龄在22至52岁之间的健康志愿者中，研究了激光诱导疼痛上行通路激活的皮质下整合效应。在眶上神经电刺激引发眨眼反射之前，受试者分别接受手部背部的二氧化碳激光刺激、第三指的指神经电刺激或第一背侧骨间肌间隙的机械轻敲。三种不同刺激方式在眨眼反射R2反应中诱导的抑制百分比相似，但发生的时间间隔不同。与对照试验相比，测试试验的R2反应在激光刺激时，250毫秒间隔时平均为23.1%；第三指电刺激时，100毫秒间隔时为17.4%；第一骨间肌间隙机械轻敲时，90毫秒间隔时为20.6%。疼痛感受器的激活在对应于缓慢传导通路的延迟时间诱导眨眼反射的前脉冲抑制。抑制百分比与其他体感输入所观察到的相似。
