Muenke M, Beachy P A
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-1852, USA.
Curr Opin Genet Dev. 2000 Jun;10(3):262-9. doi: 10.1016/s0959-437x(00)00084-8.
The disease holoprosencephaly is the basis of the most common structural anomaly of the developing forebrain in humans. Numerous teratogens when administered during early gastrulation, have been associated with this condition. Recent studies have characterized molecules expressed in the prechordal plate which are critical for normal brain formation. Perturbation of signaling pathways involving these molecules have been shown to cause holoprosencephaly in humans and other organisms.
全前脑畸形是人类发育中的前脑最常见结构异常的基础。在原肠胚形成早期给予多种致畸剂会导致这种情况。最近的研究已经确定了前索板中表达的对正常脑形成至关重要的分子。涉及这些分子的信号通路紊乱已被证明会在人类和其他生物体中导致全前脑畸形。
