有机汞化合物和巯基化合物对变形杆菌脲酶活性的影响：尿液和抗坏血酸的抑制作用。
Effect of organic mercurials and sulfhydryl compounds on the urease activity of Proteus: inhibition by urine and ascorbic acid.
作者信息
Kunin C M
出版信息
Antimicrob Agents Chemother. 1976 Sep;10(3):503-6. doi: 10.1128/AAC.10.3.503.
Meralluride, mercaptomerin, ethacrynic acid, and penicillamine inhibited urease activity of Proteus mirabilis. The activity of the organic mercurials and ethacrynic acid was markedly inhibited by human and dog urine. Antiurease activity could not be detected in the urine of a human and a dog given meralluride by injection. Urine from patients receiving penicillamine also failed to inhibit urease activity. Ascorbic acid inhibited, whereas dehydroascorbic acid enhanced, the activity of the mercurials, but neither agent altered the inhibitory effect of urine. The lethal effect of meralluride against Proteus occurred at the same concentration at which urease activity was inhibited, but penicillamine inhibited the enzymatic activity without affecting viability of the organism. The data suggest that these sulfhydryl-reactive compounds will not be useful against Proteus infections of the urinary tract.
汞撒利、汞撒明、依他尼酸和青霉胺可抑制奇异变形杆菌的脲酶活性。有机汞化合物和依他尼酸的活性受到人和狗尿液的显著抑制。给人和狗注射汞撒利后，在其尿液中未检测到抗脲酶活性。接受青霉胺治疗的患者的尿液也未能抑制脲酶活性。抗坏血酸可抑制汞化合物的活性，而脱氢抗坏血酸则增强其活性，但这两种物质均未改变尿液的抑制作用。汞撒利对变形杆菌的致死作用发生在抑制脲酶活性的相同浓度，但青霉胺抑制酶活性而不影响该生物体的生存能力。数据表明，这些巯基反应性化合物对泌尿道变形杆菌感染无效。
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