Schwenk H U, Willital G
Dtsch Med Wochenschr. 1976 Mar 19;101(12):450-4. doi: 10.1055/s-0028-1104105.
Fresh tumour cells from four children, aged 3-11 years, with malignant non-Hodgkin lymphoma were examined with four different immunological cell markers (E-rosettes, membrane-immunoglobulins, receptors for complement, and receptors for Fc fragment). In three patients a T-cell marker (E-rosettes) was found in most of their tumour cells, the marker differing from that of T-lymphcoytes by different temperature kinetics. This difference may be used to recognise earlier than previously possible the frequently observed diffuse infiltration of bone marrow (leukaemic transformation) and of the nervous system in the course of the disease.
对4名年龄在3至11岁的患有恶性非霍奇金淋巴瘤的儿童的新鲜肿瘤细胞进行了4种不同免疫细胞标志物（E玫瑰花结、膜免疫球蛋白、补体受体和Fc片段受体）的检测。在3名患者中，其大部分肿瘤细胞中发现了一种T细胞标志物（E玫瑰花结），该标志物与T淋巴细胞的标志物在温度动力学方面有所不同。这种差异可用于比以往更早地识别在疾病过程中经常观察到的骨髓弥漫性浸润（白血病转化）和神经系统浸润。
