Gaedicke G, Winkler K, Petersen N, Stein H, Landbeck G
Klin Padiatr. 1977 Jan;189(8):31-6.
29 cases of T-cell derived lymphoblastic lymphoma and T-ALL have been analyzed. There is a striking prevalence of the male sex. In the peripheral blood we often find initially an excessive number of white blood cells combined with normal values for the other constituents in about half of the patients; This may be an expression for the rapid occurrence of leukaemia in T-cell lymphosarcoma. In addition to systemic ALL-therapy we performed X-ray irradiation of the mediastinum in 8 of our patients. This yielded to significantly longer first complete remissions. All patients with T-cell LSA/ALL with or without mediastinal mass should be treated in this manner. Cytochemically a strong focal acid phosphatase reaction was found to be acharacteristic of these cells. It has proved to be a screening method for this disease. The cells are T-cell derived and their pattern of surface markers is similar to that found in fetal thymocytes.
对29例T细胞源性淋巴母细胞淋巴瘤和T细胞急性淋巴细胞白血病进行了分析。男性患病率显著。在大约一半的患者外周血中，我们最初经常发现白细胞数量过多，而其他成分的值正常；这可能是T细胞淋巴肉瘤中白血病快速发生的一种表现。除了系统性急性淋巴细胞白血病治疗外，我们对8例患者进行了纵隔X线照射。这使首次完全缓解期显著延长。所有有或无纵隔肿块的T细胞淋巴母细胞性淋巴瘤/急性淋巴细胞白血病患者均应采用这种方式治疗。细胞化学显示，这些细胞具有强烈的局灶性酸性磷酸酶反应。这已被证明是一种针对该疾病的筛查方法。这些细胞来源于T细胞，其表面标志物模式与胎儿胸腺细胞相似。
