Sakamaki K, Kanda N, Ueda T, Aikawa E, Nagata S
Institute for Virus Research, Kyoto University, Japan.
Cytogenet Cell Genet. 2000;88(3-4):246-8. doi: 10.1159/000015529.
Eosinophil peroxidase (EPX) is one of a family of mammalian peroxidases that includes myeloperoxidase (MPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO). Here we show that the human EPX gene maps to chromosome 17q23.1, which localizes 34 kb from the LPO and MPO genes. Our results demonstrate that the EPX, LPO, and MPO genes form a cluster on human chromosome 17.
嗜酸性粒细胞过氧化物酶(EPX)是哺乳动物过氧化物酶家族的一员,该家族还包括髓过氧化物酶(MPO)、乳过氧化物酶(LPO)和甲状腺过氧化物酶(TPO)。我们在此表明,人类EPX基因定位于17号染色体q23.1区,该区域距离LPO和MPO基因34 kb。我们的结果证明,EPX、LPO和MPO基因在人类17号染色体上形成一个基因簇。