Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Int J Mol Sci. 2019 Mar 21;20(6):1443. doi: 10.3390/ijms20061443.
Lactoperoxidase (LPO) present in saliva are an important element of the nonspecific immune response involved in maintaining oral health. The main role of this enzyme is to oxidize salivary thiocyanate ions (SCN) in the presence of hydrogen peroxide (H₂O₂) to products that exhibit antimicrobial activity. LPO derived from bovine milk has found an application in food, cosmetics, and medical industries due to its structural and functional similarity to the human enzyme. Oral hygiene products enriched with the LPO system constitute an alternative to the classic fluoride caries prophylaxis. This review describes the physiological role of human salivary lactoperoxidase and compares the results of clinical trials and in vitro studies of LPO alone and complex dentifrices enriched with bovine LPO. The role of reactivators and inhibitors of LPO is discussed together with the possibility of using nanoparticles to increase the stabilization and activity of this enzyme.
唾液中的乳过氧化物酶（LPO）是参与维持口腔健康的非特异性免疫反应的重要组成部分。这种酶的主要作用是在存在过氧化氢（H₂O₂）的情况下将唾液中的硫氰酸根离子（SCN）氧化为具有抗菌活性的产物。牛初乳中的 LPO 由于其结构和功能与人酶相似，已在食品、化妆品和医疗行业得到应用。富含 LPO 系统的口腔卫生用品是经典氟化物防龋的替代品。本文描述了人唾液乳过氧化物酶的生理作用，并比较了单独使用 LPO 以及富含牛 LPO 的复合牙膏的临床试验和体外研究结果。本文还讨论了 LPO 再激活剂和抑制剂的作用以及使用纳米粒子来提高这种酶的稳定性和活性的可能性。
