Odio M R, O'Connor R J, Sarbaugh F, Baldwin S
Procter & Gamble Co., Cincinnati, Ohio 45242, USA.
Dermatology. 2000;200(3):238-43. doi: 10.1159/000018366.
Diaper dermatitis is a common childhood affliction. Aiming to help reduce the prevalence of this problem, we have developed a novel diaper to deliver to the skin dermatological formulations intended to help protect the skin from overhydration and irritation.
To determine the clinical benefits of a novel disposable diaper designed to deliver a petrolatum-based formulation continuously to the skin during use.
Two independent, blinded, randomized clinical trials were conducted, involving an aggregate total of 391 children, 8-24 months of age. All comparisons were done versus a control diaper, identical to the test product except for the absence of the petrolatum formulation. The studies determined the effects of the novel diaper on skin erythema and diaper rash.
Use of the formulation-treated diaper was associated with significant reductions in severity of erythema and diaper rash compared to the control product.
The results demonstrated the clinical benefits associated with continuous topical administration of a petrolatum-based formulation by this novel diaper. We anticipate that this advance in diaper design will contribute significantly to further reduce the prevalence and severity of irritant contact dermatitis in the diaper area.
尿布疹是一种常见的儿童疾病。为了帮助降低这个问题的发生率，我们研发了一种新型尿布，可向皮肤递送旨在帮助保护皮肤免于过度水合和刺激的皮肤病学制剂。
确定一种新型一次性尿布在使用过程中持续向皮肤递送凡士林基制剂的临床益处。
进行了两项独立、双盲、随机临床试验，共纳入391名8至24个月大的儿童。所有比较均与对照尿布进行，对照尿布与测试产品相同，只是不含凡士林制剂。研究确定了新型尿布对皮肤红斑和尿布疹的影响。
与对照产品相比，使用经制剂处理的尿布可显著降低红斑和尿布疹的严重程度。
结果证明了这种新型尿布持续局部施用凡士林基制剂的临床益处。我们预计尿布设计的这一进展将极大地有助于进一步降低尿布区域刺激性接触性皮炎的发生率和严重程度。
