Gamble J F
Exxon Biomedical Sciences, Inc., Annandale, NJ 08801-0971, USA.
Occup Med (Lond). 2000 Feb;50(2):81-102. doi: 10.1093/occmed/50.2.81.
Studies of workers exposed to hydrocarbon solvents are reviewed in order to address the question, 'Does long-term human exposure to hydrocarbon solvents at concentrations around occupational exposure limits result in clinically important neurobehavioural effects?' Studies selected evaluated exposure-response (E-R) trends with some control of potential confounders. Tests of neurobehavioural performance were classified into specific functional categories, within those of cognitive, psychomotor and sensory functions to increase specificity and power to detect patterns of effect. The weight-of-evidence was evaluated with respect to criteria for determining causality. The temporality criterion was met as latency was adequate for the occurrence of chronic effects. There were few significant associations, and when present, were consistently weak even in the most-exposed workers. Exposure response showed no consistent or significant pattern for any tests of functional mortality. The weight of evidence suggests that exposure to hydrocarbon solvents at current limits does not appear to cause adverse neurobehavioural effects.
为了解决“长期接触浓度在职业接触限值左右的烃类溶剂是否会对人体产生具有临床意义的神经行为影响？”这一问题，对接触烃类溶剂的工人的研究进行了综述。所选用的研究评估了暴露-反应（E-R）趋势，并对一些潜在的混杂因素进行了控制。神经行为表现测试被归类到认知、心理运动和感觉功能等特定功能类别中，以提高检测效应模式的特异性和效能。根据确定因果关系的标准对证据权重进行了评估。由于潜伏期足以发生慢性效应，满足了时间顺序标准。几乎没有显著关联，即便存在，即使在接触程度最高的工人中也一直很微弱。对于任何功能死亡率测试，暴露反应均未显示出一致或显著的模式。证据权重表明，在当前限值下接触烃类溶剂似乎不会导致不良神经行为影响。
