Tanaka F, Origuchi T, Migita K, Tominaga M, Kawakami A, Kawabe Y, Eguchi K
First Department of Internal Medicine, Nagasaki University School of Medicine.
Intern Med. 2000 May;39(5):428-30. doi: 10.2169/internalmedicine.39.428.
Interstitial pneumonia of polymyositis and dermatomyositis (PM/DM), especially the rapid progressive type, is a serious complication. We report a case of acute exacerbated interstitial pneumonia associated with DM. The respiratory distress condition was refractory to steroid pulse therapy and cyclosporine, however, there was a good response to additional intravenous cyclophosphamide pulse therapy (IVCY). We propose the possibility that the combination of these immunosuppressants might be useful for interstitial pneumonia with DM which is resistant to conventional steroid therapies.
多发性肌炎和皮肌炎（PM/DM）的间质性肺炎，尤其是快速进展型，是一种严重的并发症。我们报告一例与皮肌炎相关的急性加重型间质性肺炎病例。呼吸窘迫状况对类固醇脉冲疗法和环孢素治疗无效，然而，追加静脉注射环磷酰胺脉冲疗法（IVCY）后有良好反应。我们提出这些免疫抑制剂联合使用可能对常规类固醇疗法耐药的皮肌炎合并间质性肺炎有用的可能性。
