Yoshida T, Koga H, Saitoh F, Sakamoto M, Harada M, Yoshida H, Sakisaka S, Sata M
Second Department of Medicine, Kurume University School of Medicine.
Intern Med. 1999 Sep;38(9):733-8. doi: 10.2169/internalmedicine.38.733.
Interstitial pneumonitis (IP) is a serious complication in polymyositis/dermatomyositis (PM/DM), leading to significant morbidity or mortality. Here, we report the successful treatment by pulse intravenous administration of cyclophosphamide in the early course of lung involvement in PM, and with subsequent low-dosage oral administration of azathioprine in a patient with steroid-resistant IP associated with PM/DM. Although the precise pharmacological mechanism induced by cyclophosphamide in this disease remains unclear, such a cytotoxic drug raises the possibility of control of steroid-resistant PM/DM-associated IP when used in the early course of IP.
间质性肺炎（IP）是多发性肌炎/皮肌炎（PM/DM）的一种严重并发症，可导致显著的发病率或死亡率。在此，我们报告了1例对类固醇耐药的与PM/DM相关的IP患者，在PM肺部受累的早期通过静脉脉冲注射环磷酰胺成功治疗，随后口服低剂量硫唑嘌呤。尽管环磷酰胺在该疾病中的确切药理机制尚不清楚，但这种细胞毒性药物在IP早期使用时增加了控制对类固醇耐药的PM/DM相关IP的可能性。
