Wiebe S, Derry P A
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Can J Neurol Sci. 2000 May;27 Suppl 1:S111-5; discussion S121-5. doi: 10.1017/s0317167100000767.
Treatment of chronic conditions often entails trade-offs between benefits and risks or side effects. This is of particular importance in epilepsy. Consequently, assessment of effectiveness must incorporate this trade-off as perceived by the recipient of the intervention, ie., the patient. Measurement of health related quality of life (HRQOL) aims at capturing such patient-centred effects of therapy. Conceptual aspects of HRQOL are described and issues relevant to outcomes of epilepsy surgery are addressed. Finally, practical aspects of measurement in the context of epilepsy surgery are discussed.
慢性病的治疗往往需要在益处与风险或副作用之间进行权衡。这在癫痫治疗中尤为重要。因此，有效性评估必须纳入干预接受者（即患者）所感知到的这种权衡。健康相关生活质量（HRQOL）的测量旨在捕捉治疗中这种以患者为中心的效果。本文描述了HRQOL的概念层面，并探讨了与癫痫手术结果相关的问题。最后，讨论了癫痫手术背景下测量的实际问题。
