联合使用的药物对长期抗凝治疗控制的影响。
Effect of concomitantly administered drugs on the control of long term anticoagulant therapy.
作者信息
Williams J R, Griffin J P, Parkins A
出版信息
Q J Med. 1976 Jan;45(177):63-73.
PMID:1083035
Abstract
The stability of control of long term anticoagulant therapy was studied in a group of 277 patients with respect to drug interactions. Increased instability (changes of dose/month of therapy) was related to the number of concomitant drugs taken irrespective of, and in addition to, known specific interactions. Fluctuating cardiac status in patients requiring digoxin and diuretic therapy was a major factor in stabilizing anticoagulant control.
摘要
在一组277例患者中，针对药物相互作用对长期抗凝治疗控制的稳定性进行了研究。不稳定性增加（每月治疗剂量变化）与所服用伴随药物的数量有关，这与已知的特定相互作用无关且是其补充。需要地高辛和利尿剂治疗的患者心脏状态波动是稳定抗凝控制的一个主要因素。
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