Cohen D, Zaide Y, Karasenty E, Schwarz M, LeDuc J W, Slepon R, Ksiazek T G, Shemer J, Green M S
Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Public Health Rev. 1999;27(1-3):217-30.
The arbovirus infections West Nile fever (WNF) and sandfly fever (SFF) are both endemic in the Middle East. Despite the fact that the mosquito and sandfly vectors of these viruses are still found in Israel, SFF has not been reported since 1948, whereas outbreaks of WNF occur periodically. It is suspected that some of the cases of nonspecific febrile illnesses in Israel may in fact be either WNF or SFF.
To determine the extent of past arbovirus infections in subgroups of Israeli soldiers.
Sera from random samples of three groups of healthy soldiers aged 18-20 (n=273), 21-30 (n=497), and 40-55 years (n=285) were examined for IgG and IgM antibodies to West Nile virus (WNV), sandfly fever Sicilian virus (SFSV), and sandfly fever Naples virus (SFNV), using an ELISA method.
The prevalence of antibodies increased with age for all three viruses examined, and ranged from 7.0%, 0, and 2.8%, for WNV, SFSV, AND SFNV, respectively, in soldiers aged 18-20 years, to 41.9%, 23.7%, and 30.8%, in those aged 40-55 years. The percentage of seropositives for IgG who were also IgM positive were 1.0%, 5.9%, and 3.4%, for WNV, SFSV, AND SFNV, respectively. 17.5% of the seropositives for WNV were also positive for SFSV, as compared with 5.7% among the WNV-seronegatives. Among the seropositives for WNV, 23.99% were positive for SFNV, compared with 9.1% of WNV seronegatives. 48.2% of seropositives for SFSV were positive for SFNV, as compared with 8.4% for SFSV-seronegatives. In the age agroup 40-55 years, there were significantly higher prevalence rates in those born in Israel compared with those born abroad.
There is still significant exposure to WNV, SFSV, and SFNV in Israel. Arborviruses are probably responsible for many cases of non-specific febrile illness in this region.
虫媒病毒感染西尼罗河热（WNF）和白蛉热（SFF）在中东地区均为地方性疾病。尽管以色列仍能发现这些病毒的蚊虫和白蛉传播媒介，但自1948年以来未再报告过白蛉热病例，而西尼罗河热疫情却周期性爆发。据推测，以色列一些非特异性发热疾病病例实际上可能是西尼罗河热或白蛉热。
确定以色列士兵亚组中过去虫媒病毒感染的程度。
采用酶联免疫吸附测定（ELISA）法，检测三组年龄分别为18 - 20岁（n = 273）、21 - 30岁（n = 497）和40 - 55岁（n = 285）的健康士兵随机样本血清中的西尼罗河病毒（WNV）、西西里白蛉热病毒（SFSV）和那不勒斯白蛉热病毒（SFNV）IgG和IgM抗体。
在所检测的三种病毒中，抗体流行率均随年龄增长而升高，在18 - 20岁士兵中，WNV、SFSV和SFNV的抗体流行率分别为7.0%、0和2.8%，而在40 - 55岁士兵中分别为41.9%、23.7%和30.8%。WNV、SFSV和SFNV IgG血清阳性且IgM也呈阳性的比例分别为1.0%、5.9%和3.4%。WNV血清阳性者中17.5%同时也为SFSV阳性，而WNV血清阴性者中这一比例为5.7%。在WNV血清阳性者中，23.99%同时为SFNV阳性，而WNV血清阴性者中这一比例为9.1%。SFSV血清阳性者中48.2%同时为SFNV阳性，而SFSV血清阴性者中这一比例为8.4%。在40 - 55岁年龄组中，出生在以色列的人患病率显著高于出生在国外的人。
在以色列，人们仍大量接触WNV、SFSV和SFNV。虫媒病毒可能是该地区许多非特异性发热疾病的病因。
