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[肛周克罗恩病的治疗]

[Treatment of perianal Crohn's disease].

作者信息

Tersigni R, Alessandroni L, Kohn A, Speziale G

机构信息

Dipartimento di Scienze Chirurgiche Struttura Complessa di Chirurgia Generale Flajani Ospedale San Camillo De Lellis, Azienda Ospedaliera San Camillo-Forlanini, Roma.

出版信息

Chir Ital. 2000 Mar-Apr;52(2):155-64.

Abstract

Perianal Crohn's disease (PACD) is defined as the presence of persistent lesions in the anal canal and perianal region in patients with Crohn's disease. The relative incidence of PACD in Crohn's disease patients ranges from 15 to 80% in the literature, depending on the accuracy of the clinical investigations and the clinical importance attributed to the lesions in the various study populations. The incidence is significantly higher if the intestinal disease is located in the colon-rectum rather than in the small bowel. We reviewed our experience in 105 patients with PACD, 32 of whom presenting rectal localisation of the primary disease. We observed 2 stenoses, 3 perirectal abscesses, 3 rectal ulcerations, 5 skin tags, 10 fissures and 77 fistulas. Two dilatations under narcosis, 2 intrarectal drainages of abscesses, 19 fistulotomies, 7 partial fistulotomies and insertion of loose setons, 47 loose setons and 4 anoperineal diversions were performed. The remaining patients received medical and topical treatments. After a median follow-up of 30 months, 90 patients (86%) showed a good response with improvement in functional scores, while 15 (14%) showed no improvement or a worsening requiring proctectomy in 13 cases. All patients submitted to proctectomy had rectal localization of the disease.

摘要

肛周克罗恩病(PACD)定义为克罗恩病患者肛管和肛周区域存在持续性病变。在文献中,克罗恩病患者中PACD的相对发病率在15%至80%之间,这取决于临床研究的准确性以及不同研究人群中对病变赋予的临床重要性。如果肠道疾病位于结肠直肠而非小肠,发病率会显著更高。我们回顾了105例PACD患者的治疗经验,其中32例原发性疾病位于直肠。我们观察到2例狭窄、3例直肠周围脓肿、3例直肠溃疡、5例皮赘、10例肛裂和77例肛瘘。进行了2次麻醉下扩张、2次直肠内脓肿引流、19次瘘管切开术、7次部分瘘管切开术并置入宽松挂线、47次宽松挂线以及4次肛门会阴转流术。其余患者接受了药物和局部治疗。中位随访30个月后,90例患者(86%)功能评分改善,反应良好,而15例(14%)无改善或病情恶化,其中13例需要行直肠切除术。所有接受直肠切除术的患者疾病均位于直肠。

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