Bodenstein H, Kalden J R, Friedrichs W, Kissling M, Troug P, von der Hardt H
Blut. 1976 Apr;32(4):285-8. doi: 10.1007/BF01005311.
Colony stimulating activity (CSA) was estimated in daily urine samples and weekly plasma specimens of a 4-year-old girl with familial cyclic neutropenia. Nadirs of neutrophils and peaks of monocytes were found in regular cycles of 28 days. A close correlation was observed between nadirs of neutrophils and peaks of blood monocytes and colony stimulating activity in the urine. The role of colony stimulating factor as regulatory factor in granulopoiesis in cyclic neutropenia is discussed.
对一名患有家族性周期性中性粒细胞减少症的4岁女孩的每日尿液样本和每周血浆样本进行了集落刺激活性(CSA)评估。发现中性粒细胞的最低点和单核细胞的峰值呈28天的规律周期出现。观察到中性粒细胞最低点、血液单核细胞峰值与尿液中的集落刺激活性之间存在密切相关性。讨论了集落刺激因子在周期性中性粒细胞减少症粒细胞生成中作为调节因子的作用。