Houba V
Bull World Health Organ. 1975;52(2):199-207.
Immune complexes play an important role in the pathogenesis of malaria-associated nephropathies. Two main types of lesion are demonstrable: (a) acute (transient-reversible) lesions typical of falciparum infections in man, with mild clinical symptoms developing a week or two after infection. Renal biopsies at that time show deposits of immunoglobulins, complement, and sometimes antigen. The lesions respond to antimalarials. (b) Chronic (progressive) lesions characteristic of quartan infections in man, developing slowly into a chronic stage with persistent proteinuria and gradually deteriorating renal function and hypertension. Renal biopsies at the onset of the disease show deposits of immunoglobulins, complement, and P. malariae antigens in glomerular capillary walls. Antimalarial therapy has no effect. Recent immunochemical findings confirm that these lesions are of the immune-complex type and are associated with malaria infection. However, several questions remain to be solved.
免疫复合物在疟疾相关性肾病的发病机制中起重要作用。可证实有两种主要类型的病变：(a) 急性（短暂可逆）病变，是人类恶性疟感染的典型表现，感染后一两周出现轻微临床症状。此时的肾活检显示有免疫球蛋白、补体沉积，有时还有抗原沉积。这些病变对抗疟药有反应。(b) 慢性（进行性）病变，是人类三日疟感染的特征，缓慢发展为慢性阶段，伴有持续性蛋白尿以及肾功能和血压逐渐恶化。疾病发作时的肾活检显示肾小球毛细血管壁有免疫球蛋白、补体和间日疟原虫抗原沉积。抗疟治疗无效。最近的免疫化学研究结果证实，这些病变属于免疫复合物类型，且与疟疾感染有关。然而，仍有几个问题有待解决。
