Whisnant J K, Rogentine G N, Gralnick M A, Schlesselman J J, Robbins J B
J Infect Dis. 1976 Apr;133(4):448-55.
Levels of antibody in serum after infection with Haemophilus influenza type b or challenge with polysaccharide vaccine are highly variable. Convalescent-phase serum antibody to the capsular polysaccharide of H. influenzae type b was measured in two groups of patients with pathophysiologically distinct diseases, meningitis and acute epiglottitis. Antibody response after H. influenzae meningitis was subnormal. Mean levels of antibody, the distribution of antibody levels by age, and erythrocyte and genetic marker lymphocyte antigens were studied; all results suggested that these two groups of patients were genetically and immunologically different from each other. Evidence suggested that the magnitude of the important host immunologic response was under host genetic control.
感染b型流感嗜血杆菌或接种多糖疫苗后血清中的抗体水平变化很大。在两组患有病理生理特征不同疾病（脑膜炎和急性会厌炎）的患者中，检测了恢复期血清中针对b型流感嗜血杆菌荚膜多糖的抗体。b型流感嗜血杆菌脑膜炎后的抗体反应低于正常水平。研究了抗体的平均水平、按年龄划分的抗体水平分布以及红细胞和遗传标记淋巴细胞抗原；所有结果表明，这两组患者在遗传和免疫方面彼此不同。有证据表明，重要的宿主免疫反应的强度受宿主基因控制。
