Bevan M J
J Exp Med. 1976 May 1;143(5):1283-8. doi: 10.1084/jem.143.5.1283.
Cytotoxic effector T cells of F1 (BALB/c X BALB.B) (H-2d/b) mice immunized against the minor histocompatibility differences of C57BL/10 (H-2b) can lyse targets from C57BL/10, but cannot lyse B10.D2 (H-2d) targets. Despite this lack of cross-reaction in the cytotoxic assay, C57BL/10 cells do prime F1 (BALB/c X BALB.B) mice for a secondary cytotoxic response to B10.D2. C57BL/10-primed, B10.D2-boosted cytotoxic cells lyse B10.D2 targets but not C57BL/10 targets. DBA/2 (H-2d) spleen cells or thymocytes prime F1 mice for a secondary response to DBA/2, B10.D2, and C57BL/10 cells, but DBA/2 mastocytes, P815, do not prime for a response to C57BL/10. Whether H-2 congenic lymphoid cells express minor histocompatibility determinants which cross-react at the cytotoxic T-cell level or the helper T-cell level is discussed.
用C57BL/10(H-2b)的次要组织相容性差异免疫的F1(BALB/c×BALB.B)(H-2d/b)小鼠的细胞毒性效应T细胞能够裂解来自C57BL/10的靶细胞,但不能裂解B10.D2(H-2d)靶细胞。尽管在细胞毒性试验中缺乏这种交叉反应,但C57BL/10细胞确实能使F1(BALB/c×BALB.B)小鼠对B10.D2产生二次细胞毒性反应。用C57BL/10致敏、B10.D2增强的细胞毒性细胞能裂解B10.D2靶细胞,但不能裂解C57BL/10靶细胞。DBA/2(H-2d)脾细胞或胸腺细胞能使F1小鼠对DBA/2、B10.D2和C57BL/10细胞产生二次反应,但DBA/2肥大细胞P815不能使小鼠对C57BL/10产生反应。本文讨论了H-2同源淋巴细胞是否表达在细胞毒性T细胞水平或辅助性T细胞水平发生交叉反应的次要组织相容性决定簇。