利用在细胞毒性试验中不发生交叉反应的H-2同基因细胞对次要组织相容性抗原进行二次细胞毒性反应的交叉呈递。
Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.
作者信息
Bevan M J
出版信息
J Exp Med. 1976 May 1;143(5):1283-8. doi: 10.1084/jem.143.5.1283.
Abstract
Cytotoxic effector T cells of F1 (BALB/c X BALB.B) (H-2d/b) mice immunized against the minor histocompatibility differences of C57BL/10 (H-2b) can lyse targets from C57BL/10, but cannot lyse B10.D2 (H-2d) targets. Despite this lack of cross-reaction in the cytotoxic assay, C57BL/10 cells do prime F1 (BALB/c X BALB.B) mice for a secondary cytotoxic response to B10.D2. C57BL/10-primed, B10.D2-boosted cytotoxic cells lyse B10.D2 targets but not C57BL/10 targets. DBA/2 (H-2d) spleen cells or thymocytes prime F1 mice for a secondary response to DBA/2, B10.D2, and C57BL/10 cells, but DBA/2 mastocytes, P815, do not prime for a response to C57BL/10. Whether H-2 congenic lymphoid cells express minor histocompatibility determinants which cross-react at the cytotoxic T-cell level or the helper T-cell level is discussed.
摘要
用C57BL/10（H-2b）的次要组织相容性差异免疫的F1（BALB/c×BALB.B）（H-2d/b）小鼠的细胞毒性效应T细胞能够裂解来自C57BL/10的靶细胞，但不能裂解B10.D2（H-2d）靶细胞。尽管在细胞毒性试验中缺乏这种交叉反应，但C57BL/10细胞确实能使F1（BALB/c×BALB.B）小鼠对B10.D2产生二次细胞毒性反应。用C57BL/10致敏、B10.D2增强的细胞毒性细胞能裂解B10.D2靶细胞，但不能裂解C57BL/10靶细胞。DBA/2（H-2d）脾细胞或胸腺细胞能使F1小鼠对DBA/2、B10.D2和C57BL/10细胞产生二次反应，但DBA/2肥大细胞P815不能使小鼠对C57BL/10产生反应。本文讨论了H-2同源淋巴细胞是否表达在细胞毒性T细胞水平或辅助性T细胞水平发生交叉反应的次要组织相容性决定簇。
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