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表儿茶素 F 和儿茶素 I：两种从艳山姜种子中分离得到的新型具有抗增殖活性的二芳基庚烷类化合物。

Epicalyxin F and calyxin I: two novel antiproliferative diarylheptanoids from the seeds of Alpinia blepharocalyx.

作者信息

Gewali M B, Tezuka Y, Banskota A H, Ali M S, Saiki I, Dong H, Kadota S

机构信息

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Org Lett. 1999 Dec 2;1(11):1733-6. doi: 10.1021/ol990260p.

DOI:10.1021/ol990260p
PMID:10836033
Abstract

[formula: see text] Epicalyxin F (1) and calyxin I (2), two novel diarylheptanoids, were isolated from a residual fraction of an EtOH extract of Alpinia blepharocalyx. Calyxin I (2) represented a new carbon skeleton, and epicalyxin F (1) possessed potent antiproliferative activity toward HT-1080 fibrosarcoma and colon 26-L5 carcinoma with ED50 values of 1.71 and 0.89 microM, respectively.

摘要

[化学式：见正文] 表儿茶素F（1）和儿茶素I（2）是从毛萼山姜乙醇提取物的残余部分中分离得到的两种新型二芳基庚烷类化合物。儿茶素I（2）代表一种新的碳骨架，表儿茶素F（1）对HT-1080纤维肉瘤和结肠26-L5癌具有较强的抗增殖活性，其半数有效剂量（ED50）值分别为1.71和0.89微摩尔。

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