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从番荔枝种子中分离得到的具有细胞毒性的双四氢呋喃番荔枝烷型乙酰二萜类化合物。

Cytotoxic bistetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa.

机构信息

College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210046, People's Republic of China.

出版信息

J Nat Prod. 2011 Nov 28;74(11):2477-81. doi: 10.1021/np200708q. Epub 2011 Oct 19.

DOI:10.1021/np200708q
PMID:22011319
Abstract

Three new bistetrahydrofuran annonaceous acetogenins (1-3) were isolated from a 95% EtOH extract of Annona squamosa seeds. Four known annonaceous acetogenins, uvarigrandin A (4), bullatacin (5), squamostatin-A (6), and squamostatin-D (7), were also isolated. Their structures were elucidated by spectroscopic analyses, and the absolute configurations of the carbinol centers of 1-3 were defined by application of the Mosher method. These compounds all exhibited significant cytotoxic activity in vitro against five human tumor cell lines.

摘要

从番荔枝种子的 95%乙醇提取物中分离得到三种新的双四氢呋喃番荔枝烷型乙酰氧基化合物（1-3）。还分离得到了四种已知的番荔枝烷型乙酰氧基化合物，包括 uvarigrandin A（4）、bullatacin（5）、squamostatin-A（6）和 squamostatin-D（7）。通过光谱分析阐明了它们的结构，并通过应用 Mosher 方法确定了 1-3 的手性碳原子的绝对构型。这些化合物在体外对五种人肿瘤细胞系均表现出显著的细胞毒性活性。

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