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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Schruers K, Pols H, Overbeek T, Griez E

University of Maastricht, Department of Psychiatry and Neuropsychology and Academic Anxiety Center, The Netherlands.

Prog Neuropsychopharmacol Biol Psychiatry. 2000 Apr;24(3):409-18. doi: 10.1016/s0278-5846(99)00108-6.

The purpose of the study was to confirm whether a subthreshold dose of CCK-4 would enhance the vulnerability of healthy subjects to a 35% carbon dioxide challenge. 2. 40 subjects, with no prior or present psychiatric disorder and in good physical health were challenged with a vital capacity breath of a 35% carbon dioxide 65% oxygen mixture, immediately after an intravenous injection of 10 microg CCK-4 or placebo, according to a random order, double blind, separate group design. 3. Subjects reported significantly less anxiety and panic symptoms upon carbon dioxide after premedication with CCK-4 than after placebo. 4. CCK-4 and carbon dioxide seem to inhibit rather than enhance each other's effects, possibly through an effect on different neurobiological systems.

该研究的目的是确认亚阈值剂量的CCK - 4是否会增加健康受试者对35%二氧化碳激发试验的易感性。2. 40名既往及目前均无精神疾病且身体健康的受试者，按照随机顺序、双盲、分组设计，在静脉注射10微克CCK - 4或安慰剂后，立即接受35%二氧化碳与65%氧气混合气体的肺活量呼吸激发试验。3. 与接受安慰剂后相比，CCK - 4预处理后，受试者在二氧化碳激发试验时报告的焦虑和惊恐症状明显减轻。4. CCK - 4和二氧化碳似乎相互抑制而非增强彼此的作用，这可能是通过对不同神经生物学系统的影响实现的。

Schruers K, Pols H, Overbeek T, Griez E

University of Maastricht, Department of Psychiatry and Neuropsychology and Academic Anxiety Center, The Netherlands.

Prog Neuropsychopharmacol Biol Psychiatry. 2000 Apr;24(3):409-18. doi: 10.1016/s0278-5846(99)00108-6.

The purpose of the study was to confirm whether a subthreshold dose of CCK-4 would enhance the vulnerability of healthy subjects to a 35% carbon dioxide challenge. 2. 40 subjects, with no prior or present psychiatric disorder and in good physical health were challenged with a vital capacity breath of a 35% carbon dioxide 65% oxygen mixture, immediately after an intravenous injection of 10 microg CCK-4 or placebo, according to a random order, double blind, separate group design. 3. Subjects reported significantly less anxiety and panic symptoms upon carbon dioxide after premedication with CCK-4 than after placebo. 4. CCK-4 and carbon dioxide seem to inhibit rather than enhance each other's effects, possibly through an effect on different neurobiological systems.

该研究的目的是确认亚阈值剂量的CCK - 4是否会增加健康受试者对35%二氧化碳激发试验的易感性。2. 40名既往及目前均无精神疾病且身体健康的受试者，按照随机顺序、双盲、分组设计，在静脉注射10微克CCK - 4或安慰剂后，立即接受35%二氧化碳与65%氧气混合气体的肺活量呼吸激发试验。3. 与接受安慰剂后相比，CCK - 4预处理后，受试者在二氧化碳激发试验时报告的焦虑和惊恐症状明显减轻。4. CCK - 4和二氧化碳似乎相互抑制而非增强彼此的作用，这可能是通过对不同神经生物学系统的影响实现的。