Pols H, Griez E, Verburg K, van der Werf D
State University of Limburg, Academic Psychiatric Center, Maastricht, The Netherlands.
Eur Arch Psychiatry Clin Neurosci. 1994;244(2):81-5. doi: 10.1007/BF02193523.
A group of 20 healthy volunteers underwent a 35% carbon dioxide/65% oxygen air-placebo controlled challenge test twice, premedicated 1 h before with either 20 mg yohimbine or placebo, following a double-blind randomized crossover design. Contrary to expectation the anxiety response to carbon dioxide was not higher when premedicated with yohimbine compared to premedication with placebo. Possible implications of this finding are discussed, with reference to general chemical models of panic.
一组20名健康志愿者按照双盲随机交叉设计，在两次35%二氧化碳/65%氧气空气-安慰剂对照激发试验前1小时，分别预先服用20毫克育亨宾或安慰剂。与预期相反，与服用安慰剂相比，服用育亨宾预处理后对二氧化碳的焦虑反应并不更高。结合惊恐的一般化学模型，讨论了这一发现可能的影响。
