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从蓝桉茎皮中分离出的某些成分的脂质过氧化抑制活性。

Lipid peroxidation inhibitory activity of some constituents isolated from the stem bark of Eucalyptus globulus.

作者信息

Yun B S, Lee I K, Kim J P, Chung S H, Shim G S, Yoo I D

机构信息

Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon.

出版信息

Arch Pharm Res. 2000 Apr;23(2):147-50. doi: 10.1007/BF02975503.

DOI:10.1007/BF02975503
PMID:10836740
Abstract

Twelve compounds with lipid peroxidation inhibitory activity were isolated from the stem bark of E. globulus. Their structures were assigned as a new aromatic monoterpene (1) and eleven known compounds, pinoresinol (2), vomifoliol (3), 3,4,5-trimethoxyphenol 1-O-beta-D-(6'-O-galloyl)glucopyranoside (4), methyl gallate (5), rhamnazin (6), rhamnetin (7), eriodictyol (8), quercetin (9), taxifolin (10), engelitin (11), and catechin (12) on the basis of UV, mass, and NMR spectroscopic analyses. These compounds except vomifoliol significantly inhibited lipid peroxidation in rat liver microsome.

摘要

从蓝桉茎皮中分离出12种具有脂质过氧化抑制活性的化合物。通过紫外光谱、质谱和核磁共振光谱分析，确定它们的结构分别为一种新的芳香单萜（1）和11种已知化合物，即松脂醇（2）、vomifoliol（3）、3,4,5-三甲氧基苯酚1-O-β-D-（6'-O-没食子酰基）吡喃葡萄糖苷（4）、没食子酸甲酯（5）、鼠李嗪（6）、鼠李素（7）、圣草酚（8）、槲皮素（9）、紫杉叶素（10）、恩格勒苷脂素（11）和儿茶素（12）。除vomifoliol外，这些化合物均能显著抑制大鼠肝微粒体中的脂质过氧化。

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