Schlag G, Schliep H J, Dingeldein E, Grieben A, Ringsdorf W
Anaesthesist. 1976 Feb;25(2):60-7.
Cardiovascular experiments in dogs and rabbits under various conditions demonstrated that monomethylacrylate has no direct cardiac depressant activity. The transient decrease in blood pressure and heart rate of patients receiving endoprostheses and experimental animals is elicited by a vagotropic effect of the methacrylates and can be antagonized by prophylactic application of atropine. Severe cardiovascular incidents involving an acute cor pulmonale are induced via the steep rise in pressure within the bone-marrow canal during the forcing in of the endoprosthetic shafts, leading to intravasation of bone marrow and its thromboplastine like compounds, thus resulting in a partial coagulation. A schedule of simple prophylactic procedures proved to be effective in preventing fatal cardiovascular complications.
在各种条件下对犬和兔进行的心血管实验表明，单甲基丙烯酸酯没有直接的心脏抑制活性。接受内置假体的患者和实验动物出现的血压和心率短暂下降是由甲基丙烯酸酯的迷走神经效应引起的，并且可以通过预防性应用阿托品来对抗。在强行插入内置假体杆的过程中，骨髓腔内压力急剧上升，引发涉及急性肺心病的严重心血管事件，导致骨髓及其类凝血活酶化合物进入血管，从而引起部分凝血。事实证明，一套简单的预防程序在预防致命的心血管并发症方面是有效的。
