Vidgren MT, Kublik H
Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland
Adv Drug Deliv Rev. 1998 Jan 5;29(1-2):157-177. doi: 10.1016/s0169-409x(97)00067-7.
Due to nasal anatomy and physiology, with a non-ciliated area in the anterior part of the nasal cavity and a ciliated region in the more posterior part of the nose, the site of deposition is of importance for the nasal mucociliary clearance and retainment of a formulation in the nose. Many drug delivery devices for nasal application of liquid, semisolid and solid formulations were investigated in respect to their deposition in the nasal cavity. The site of deposition and the deposition area depend on several parameters which are related to the delivery device, such as mode of administration, particle size of the formulation and velocity of the delivered particles. Several in vitro and in vivo methods have been used to study distribution and clearance of intranasally delivered therapeutics. The relationship between deposition, absorption and related bioavailability of the nasally applied formulation has been shown.
由于鼻腔的解剖结构和生理特点，鼻腔前部存在无纤毛区域，而鼻腔后部为纤毛区域，因此制剂在鼻腔内的沉积部位对于鼻黏液纤毛清除以及制剂在鼻腔内的滞留具有重要意义。针对用于鼻腔给药的液体、半固体和固体剂型的许多给药装置，人们研究了它们在鼻腔内的沉积情况。沉积部位和沉积区域取决于与给药装置相关的几个参数，例如给药方式、制剂的粒径以及所输送颗粒的速度。已经采用了多种体外和体内方法来研究经鼻给药治疗药物的分布和清除情况。鼻用制剂的沉积、吸收及相关生物利用度之间的关系已得到证实。
