Fleming A, Dodman S, Crown J M, Corbett M
Br Med J. 1976 May 22;1(6020):1241-3. doi: 10.1136/bmj.1.6020.1241.
One hundred and two patients who presented with rheumatoid disease within the first year of onset were studied prospectively every four months for a mean 4.5 years to assess the incidence of extra-articular features. The features that seemed to be common in the early stages included hand-muscle wasting, carpal tunnel syndrome, lymphadenopathy, non-specific ankle swelling, and rheumatoid nodules, and to a lesser extent hepatomegaly, being underweight, conjunctivitis, skin transparency, and a palpable thyroid gland. Those features which seldom occurred early included scleromalacia, temporal artery inolvement, salivary gland enlargement, distal-motor neuropathy, splenomegaly, digital vasculitis, and pulmonary and cardiac complications. Being underweight indicated a significantly more severe outcome.
对102例发病第一年内出现类风湿病的患者进行前瞻性研究，每四个月进行一次检查，平均持续4.5年，以评估关节外表现的发生率。早期似乎常见的表现包括手部肌肉萎缩、腕管综合征、淋巴结病、非特异性踝关节肿胀和类风湿结节，程度较轻的有肝肿大、体重过轻、结膜炎、皮肤透明度增加和可触及的甲状腺。早期很少出现的表现包括软化症、颞动脉受累、唾液腺肿大、远端运动神经病、脾肿大、指端血管炎以及肺部和心脏并发症。体重过轻表明预后明显更差。
