Spahn D R
Institut für Anästhesiologie, UniversitätsSpital, Zürich, Switzerland.
Adv Drug Deliv Rev. 2000 Feb 28;40(3):143-51. doi: 10.1016/s0169-409x(99)00046-0.
Artificial oxygen carriers may be grouped into modified hemoglobin solutions and fluorocarbon emulsions. In animal experiments, both have been shown to be efficacious in improving tissue oxygenation and as substitutes for blood transfusions. Advantages and disadvantages are being discussed in this article as well as the latest steps in the clinical development.
人工氧载体可分为改良血红蛋白溶液和氟碳乳剂。在动物实验中,两者均已证明在改善组织氧合以及作为输血替代品方面是有效的。本文将讨论其优缺点以及临床开发的最新进展。