Weingart Christiane, Kohn Barbara
Clinic for Small Animals, Faculty of Veterinary Medicine, Free University of Berlin, Oertzenweg 19b, Berlin, Germany.
J Feline Med Surg. 2008 Oct;10(5):431-8. doi: 10.1016/j.jfms.2007.10.012. Epub 2008 May 2.
The objective of this retrospective study was the evaluation of the administration of a haemoglobin (Hb)-based oxygen carrying solution (Oxyglobin) to cats over a time period of 4 years. Indication, infusion volume/24h, number of Oxyglobin infusions/cat, Hb concentration pre- and post-infusion, adverse events, and patient outcome were evaluated. Forty-eight anaemic cats received 65 Oxyglobin infusions. Prior to administration of Oxyglobin, Hb concentration ranged from 2 to 7.8 g/dl (median 4.9 g/dl), the volume of Oxyglobin administered was 4.4-25 ml/kg/24h (median 9.8 ml/kg/24h). An increase of Hb was noted after 41 of 49 infusion events. Severe side effects were noted in seven cats with cardiac disease, which developed pulmonary oedema (five), pleural effusion (three), and respiratory distress (one). They received 6.7-19.8 ml/kg/24h (median 12.3 ml/kg/24h) of Oxyglobin. Four of these seven cats received whole blood transfusions on the same day; five cats died and one was euthanased. Overall 24-h survival rate was 77%. Administration of Oxyglobin efficiently increased the Hb concentration. However, in cats suffering from cardiac disease, there is a high risk of life-threatening circulatory overload at the doses used in this study.
这项回顾性研究的目的是评估在4年时间里给猫使用基于血红蛋白（Hb）的携氧溶液（Oxyglobin）的情况。对用药指征、每24小时输注量、每只猫Oxyglobin输注次数、输注前后的Hb浓度、不良事件及患者结局进行了评估。48只贫血猫接受了65次Oxyglobin输注。在给予Oxyglobin之前，Hb浓度范围为2至7.8 g/dl（中位数为4.9 g/dl），给予的Oxyglobin量为4.4 - 25 ml/kg/24h（中位数为9.8 ml/kg/24h）。49次输注事件中有41次输注后Hb有所升高。7只患有心脏病的猫出现了严重副作用，包括肺水肿（5只）、胸腔积液（3只）和呼吸窘迫（1只）。它们接受了6.7 - 19.8 ml/kg/24h（中位数为12.3 ml/kg/24h）的Oxyglobin。这7只猫中有4只在同一天接受了全血输注；5只猫死亡，1只被安乐死。总体24小时生存率为77%。Oxyglobin的使用有效提高了Hb浓度。然而，在患有心脏病的猫中，本研究使用的剂量存在危及生命的循环超负荷高风险。
