Rothenbacher D, Inceoglu J, Bode G, Brenner H
Department of Epidemiology, University of Ulm, Germany.
J Pediatr. 2000 Jun;136(6):744-8.
To elucidate age at acquisition of Helicobacter pylori infection, we conducted a study in a population of children known to be at high risk for H pylori infection.
Children with no symptoms who were of Turkish nationality and living in the city of Ulm, Germany, and nearby communities and on whom routine health screening examinations were performed at age 1 year (56 children), 2 years (55 children), or 4 years (69 children) were included in this cross-sectional study. Stool samples were collected by the parents and sent by mail to the University of Ulm. An H pylori antigen enzyme immunoassay for the detection of H pylori in stool was used to define current infection status. Sensitivity was 84.6% (95% CI 63. 1% to 94.7%) and specificity 97.7% (95% CI 86.2% to 99.9%) in the 4-year-old children in whom the stool test was compared with the (13)C-urea breath test.
The prevalence of infection was 8. 9% (95% CI 3.0% to 19.6%) among the 1-year-old children, 36.4% (95% CI 23.8% to 50.4%) among the 2-year-old children, and 31.9% (95% CI 21.2% to 44.2%) among the 4-year-old children.
In this high-risk group of Turkish children living in Germany, H pylori acquisition seems to occur mainly between the first and the second years of life. Therefore preventive measures such as vaccination necessitate application early in infancy. Further studies are now required to ascertain the mechanisms for transmission in this age group.
为了阐明幽门螺杆菌感染的获得年龄，我们在一群已知幽门螺杆菌感染高危儿童中开展了一项研究。
本横断面研究纳入了无症状的土耳其国籍儿童，他们生活在德国乌尔姆市及其附近社区，且在1岁（56名儿童）、2岁（55名儿童）或4岁（69名儿童）时接受了常规健康筛查。粪便样本由家长采集并邮寄至乌尔姆大学。采用一种用于检测粪便中幽门螺杆菌的幽门螺杆菌抗原酶免疫测定法来确定当前感染状态。在将粪便检测与（13）C-尿素呼气试验进行比较的4岁儿童中，敏感性为84.6%（95%可信区间63.1%至94.7%），特异性为97.7%（95%可信区间86.2%至99.9%）。
1岁儿童中的感染率为8.9%（95%可信区间3.0%至19.6%），2岁儿童中的感染率为36.4%（95%可信区间23.8%至50.4%），4岁儿童中的感染率为31.9%（95%可信区间21.2%至44.2%）。
在这群生活在德国的土耳其高危儿童中，幽门螺杆菌感染似乎主要发生在1岁至2岁之间。因此，诸如疫苗接种等预防措施需要在婴儿期早期应用。现在需要进一步研究以确定该年龄组的传播机制。
