Krammer P H, Pernis B
Scand J Immunol. 1976;5(3):199-204. doi: 10.1111/j.1365-3083.1976.tb00270.x.
This study demonstrated that Fc rosettes detected by antibody-labeled bovine erythrocytes can be inhibited by immune complexes of rabbit IgG (b4 allotype) and anti-b4 IgG, thus showing that these complexes effectively compete for the receptor for erythrocyte-antibody rosettes. Incubation of mouse lymphocytes with goat F(ab')2 anti-mouse IgG did not inhibit Fc rosettes. When immunoglobulin on murine and human B lymphocytes was redistributed in a polar cap on the membrane by interaction with anti-immunoglobulin antibodies, the number of Fc rosettes after 'capping' was unchanged; most of the indicator erythrocytes, however, were distributed in a cap as well. This erythrocyte cap was superimposed on the immunoglobulin cap.
本研究表明，用抗体标记的牛红细胞检测到的Fc玫瑰花结可被兔IgG（b4同种异型）和抗b4 IgG的免疫复合物所抑制，从而表明这些复合物有效地竞争红细胞 - 抗体玫瑰花结的受体。用山羊F(ab')2抗小鼠IgG孵育小鼠淋巴细胞不会抑制Fc玫瑰花结。当通过与抗免疫球蛋白抗体相互作用使鼠和人B淋巴细胞上的免疫球蛋白重新分布在膜上的极帽中时，“封帽”后Fc玫瑰花结的数量未发生变化；然而，大多数指示红细胞也分布在一个帽中。这个红细胞帽叠加在免疫球蛋白帽上。
