Goldschmidt L, Day N L, Richardson G A
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 15213, Pittsburgh, PA, USA.
Neurotoxicol Teratol. 2000 May-Jun;22(3):325-36. doi: 10.1016/s0892-0362(00)00066-0.
This is a prospective study of the effects of prenatal marijuana exposure on child behavior problems at age 10. The sample consisted of low-income women attending a prenatal clinic. Half of the women were African-American and half were Caucasian. The majority of the women decreased their use of marijuana during pregnancy. The assessments of child behavior problems included the Child Behavior Checklist (CBCL), Teacher's Report Form (TRF), and the Swanson, Noland, and Pelham (SNAP) checklist. Multiple and logistic regressions were employed to analyze the relations between marijuana use and behavior problems of the children, while controlling for the effects of other extraneous variables. Prenatal marijuana use was significantly related to increased hyperactivity, impulsivity, and inattention symptoms as measured by the SNAP, increased delinquency as measured by the CBCL, and increased delinquency and externalizing problems as measured by the TRF. The pathway between prenatal marijuana exposure and delinquency was mediated by the effects of marijuana exposure on inattention symptoms. These findings indicate that prenatal marijuana exposure has an effect on child behavior problems at age 10.
这是一项关于产前接触大麻对10岁儿童行为问题影响的前瞻性研究。样本包括在产前诊所就诊的低收入女性。其中一半女性是非裔美国人，另一半是白人。大多数女性在孕期减少了大麻的使用。对儿童行为问题的评估包括儿童行为清单（CBCL）、教师报告表（TRF）以及斯旺森、诺兰德和佩勒姆（SNAP）清单。在控制其他无关变量影响的同时，采用多元回归和逻辑回归分析大麻使用与儿童行为问题之间的关系。产前使用大麻与SNAP量表所测量的多动、冲动和注意力不集中症状增加显著相关，与CBCL量表所测量的违法犯罪行为增加显著相关，与TRF量表所测量的违法犯罪行为和外化问题增加显著相关。产前接触大麻与违法犯罪行为之间的途径由大麻接触对注意力不集中症状的影响介导。这些研究结果表明，产前接触大麻会对10岁儿童的行为问题产生影响。
