Peppas N A, Bures P, Leobandung W, Ichikawa H
Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette IN 47907-1283, USA.
Eur J Pharm Biopharm. 2000 Jul;50(1):27-46. doi: 10.1016/s0939-6411(00)00090-4.
The availability of large molecular weight protein- and peptide-based drugs due to the recent advances in the field of molecular biology has given us new ways to treat a number of diseases. Synthetic hydrogels offer a possibly effective and convenient way to administer these compounds. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as pH, ionic strength and temperature. The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
由于分子生物学领域最近的进展，基于大分子蛋白质和肽的药物的可得性为我们提供了治疗多种疾病的新方法。合成水凝胶为施用这些化合物提供了一种可能有效且方便的方式。水凝胶是亲水性的三维网络，能够吸收大量的水或生物流体，因此在很大程度上类似于生物组织。由于存在化学（连接点、交联）和/或物理交联，如缠结和微晶，它们是不溶性的。这些材料可以被合成以响应体内存在的多种生理刺激，如pH值、离子强度和温度。本文的目的是对水凝胶在制药领域的应用、水凝胶表征以及此类装置的药物释放分析进行简要综述。
