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锌镁化合物和纳米羟基磷灰石对用于骨软骨缺损的藻酸盐和明胶支架的物理化学性质及生物活性的影响

Effect of Zinc and Magnesium Compounds and Nano-Hydroxyapatite on the Physicochemical Properties and Biological Activity of Alginate and Gelatin Scaffolds for Osteochondral Defects.

作者信息

Morawska-Chochół Anna, Urbaś Agnieszka, Reczyński Witold, Kwiecień Ewelina, Rzewuska Magdalena

机构信息

Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Krakow, 30-059 Krakow, Poland.

Faculty of Electrical Engineering, Automatics, Computer Science and Biomedical Engineering, AGH University of Krakow, 30-059 Krakow, Poland.

出版信息

J Funct Biomater. 2025 Aug 19;16(8):300. doi: 10.3390/jfb16080300.

DOI:10.3390/jfb16080300
PMID:40863320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12387271/
Abstract

Composite scaffolds based on a hydrogel matrix modified with hydroxyapatite, magnesium, or zinc compounds are promising for filling and regenerating osteochondral defects due to the specific biological properties of these modifiers. The aim of this work was to evaluate the influence of hydroxyapatite, nano-hydroxyapatite, magnesium chloride, and zinc oxide on mechanical properties, swelling ability, behavior in a simulated biological environment (ion release, stability, bioactivity), and antibacterial effects. Furthermore, the influence of the hydrogel matrix (alginate, gelatin, alginate/gelatin) on the selected properties was also assessed. The results showed that the addition of ZnO improved the mechanical properties of all types of matrices most effectively. Additionally, zinc ions were gradually released into the environment and partially incorporated into the formed apatite. The released zinc ions increased the inhibition zones of growth; however, this effect was observed only in scaffolds with an alginate matrix. This indicates that hydrogel plays a key role in antibacterial effects, beyond the contribution of antibacterial additives. No effect of magnesium on bacterial growth inhibition was observed despite its rapid release. Magnesium ions promoted efficient secretion of apatite during incubation, although it was not stable. The addition of nano-HAP significantly increased the stability of the apatite precipitates.

摘要

基于用羟基磷灰石、镁或锌化合物改性的水凝胶基质的复合支架，由于这些改性剂的特定生物学特性，有望用于填充和再生骨软骨缺损。这项工作的目的是评估羟基磷灰石、纳米羟基磷灰石、氯化镁和氧化锌对机械性能、膨胀能力、在模拟生物环境中的行为（离子释放、稳定性、生物活性）以及抗菌效果的影响。此外，还评估了水凝胶基质（藻酸盐、明胶、藻酸盐/明胶）对所选性能的影响。结果表明，添加氧化锌最有效地改善了所有类型基质的机械性能。此外，锌离子逐渐释放到环境中并部分掺入形成的磷灰石中。释放的锌离子增加了生长抑制区；然而，这种效果仅在具有藻酸盐基质的支架中观察到。这表明水凝胶在抗菌效果中起关键作用，超出了抗菌添加剂的作用。尽管镁快速释放，但未观察到其对细菌生长抑制的影响。镁离子在孵育过程中促进了磷灰石的有效分泌，尽管其不稳定。添加纳米羟基磷灰石显著提高了磷灰石沉淀的稳定性。

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